whate is difference between calibration and validation
- 11 Answers
- 43134 Views
- Alkem Labs, Cipla, Ranbaxy, Torrent Pharma, Zydus Cadila, I also Faced
- E-Mail Answers
Answers were Sorted based on User's Feedback
Answer / siddhesh
Calibration is a tool to ensure that the instrument or equipment is working well & Validation is a tool to ensure that the analytical method is working well.
| Is This Answer Correct ? | 64 Yes | 7 No |
Answer / thiruathi swamy
Validation mean documented evidence that a particular
instrument or process produce results meet predetermined
specification.
Calibration means particular instrument or device produce
results by comparison of known reference standard.
| Is This Answer Correct ? | 39 Yes | 3 No |
Answer / ragav
Validation in the pharmaceutical and medical device
industry is defined as the documented act of demonstrating
that a procedure, process, and activity will consistently
lead to the expected results.
Making measurements with any analytical method or
instrument requires calibration to ensure the accuracy of
the measurement. There are two common calibration
procedures: using a working curve, and the standard-
addition method. Both of these methods require one or more
standards of known composition to calibrate the
measurement.
| Is This Answer Correct ? | 23 Yes | 9 No |
will calibratin only for instruments ,. but we can perform
validation not only for instuments for method allso,,..
calibratiom = checking the instrument with standards
validation = validating the existing method or instrument
| Is This Answer Correct ? | 13 Yes | 0 No |
Answer / arvind singh yadav
Validation is a documented program that provides high degree of assurance that a specific process, equipment, method or system consistently produces a result meeting pre-determined acceptance criteria.Shall be performed as per validation protocol.
Calibration is a demonstration that, a particular Instrument or device produces results with in specified limits by comparisons with those produced by a reference or traceable standard over an appropriate range of measurements.Shall be performed as per calibration SOP.
| Is This Answer Correct ? | 11 Yes | 1 No |
Answer / chandra bhushan tiwari
Calibration is done by known device (standard)againt the
the unknown device, it means instrument are working
properly or not and can be adjusted within tolerance.
Validation is to ensure the method which is to be used for
its intended purpose or not.
| Is This Answer Correct ? | 10 Yes | 1 No |
Answer / nirav panchal
Calibration is done to nulify or remove the deviation by comparing with known or reference standard,
while Validation is done to prove that Consistency of expacted results of Process,Method,or Procedure
| Is This Answer Correct ? | 6 Yes | 2 No |
calibration:is to check instrument working condition with standards
validation: is to make shore that instrument and methods and processare consistently producing repeatable results as per in house requirement .
calibration gives assurance about only instrument but validation gives assurance about method, and process and man instruments
| Is This Answer Correct ? | 1 Yes | 0 No |
Answer / nimesh trivedi
Calibration means system performance checking
Validations means Mfg. Process or analytical method performance checking
| Is This Answer Correct ? | 0 Yes | 0 No |
why r u using hplc grade solvents
hii, i'm had a sample of 1L that gone through extraction & evaporation. i used 0.5ml of methanol for reconstitution before injecting the sample to HPLC. i made a calibration curve using a standard solution but now i'm confused about how to display the concentration i got from the sample. for ex. i got 0.2ug/ml how i'm gonna explane this is for the 1L ? please help .. i'll really appreciate it thanks
in dissolution why pool sample needed? in which type of drug pool sample need?
One Raw material failed assay test is there any chance for failing purity of that material ?
What is the main difference between ODS1 and ODS2 Hplc column.
What is the definition of RRF
how can give the expiry period and restadardisation of volumetric solution
0 Answers Meenaxy Pharma, SRF,
Difference between c18
6 Answers Dr Reddys, Intas, Torrent Pharma, Apothecon, IPQA, SUN,
wat is the role of michelson interferometer in FTIR and He-Ne lase.detailed answer required in simple language
What is Endcapped Hplc column
Why potassium dichromate is used in calibration of uv?
Why use only methanol,used determinationof moisture content not use other solvents
Organic Chemistry 
