what is rt and rrt? how we find rrt? relation between rt and rrt/
Answer / harshad raj
In HPLC & GC :
The RT means, in which time the main principle peak of component is retain in minute called RT as retention time. and the RRT means: in which time the impurity peaks are retained before and after the main principle peak and that retention time of impurity peaks called RRT, ie. relative retention time RRT to the base of main peak RT.
The relation between RT & RRT is always the main peak RRT is 1.0 and the impurity peak RRT calculation is IMPURITY PEAK RT / MAIN PEAK RT.
For example: The main peak RT is 15 MIn, and the Impurity RT is 5 Min,
The RRT of Main Peak is 15/15 = 1
The RRT of Impurity peak is 5/15 = 0.333...
| Is This Answer Correct ? | 33 Yes | 3 No |
Explain in detail what are the procedure and calculations involved for accuracy (%Recovery)in method validation?
is it necessary to do HPLC calibration at wavelength 315nm if we are doing analysis at this wavelangth
When i inject amines and acid on HPLC then which peak will elut first?
what is dissolution
Is it required to inject 6 injections for % RSD of a system suitability in lc or gc
In case of dissolution test, if there is variation within 6 individual units however the batch is complying as per S1 criteria, is it necessary to do investigation for the same? What should be the criteria for such variation?
How can the GC or HPLC method is selected to determine the impurity profile in drug product?
why we use only six bowls for dissolution of a drug
1 Answers Cipla, Natco, TelePerformance,
in which situation require to use paddle and basket?
Difference between standard operating procedure and standard test procedures in pharmaceutical industry
How to establish pKa for a new API molecule ?
2 Answers Neuland, Sun Pharma,
What are usp limits for theoritical plats,resoution,tailing factor,peak to valley ratio