Answer / mukesh patel

impurity can be calculated against impurity when impurity
availability is sufficient.and easily available for routine
analysis and there is huge difference in RF or RRF with
main analylte.impurity can be calculated against diluted
standard with applying RRF when peak get saturated in
sample solution.

Answer / sp goswami

We need calc of imp RRF against impurity std when our
impurity responses are improper with st. phase of that
column and also if imp. is available in sufficient quantity
for diluted std we can cal for quantified results and if
impurity is less in amount and response is also less ,so to
get a perfect calculated % impurity we quantify it with
help of diluted std.
Regards

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