Answer / rajendra gaikawad

I think , our body constitute various chemical compounds i.e HCL , Phosphate buffer,acetate buffer.
Hence when we make any new product,whether that product release the drug in these different medium or not.
Since sometimes the site of action is different and whether our drug will release the drug in other medium or not.
Hence to ckeck drug release other than stomach multimedia dissolution profiling is done.

Answer / sandeep singh

If the dissolution is slower
than gastric emptying, a dissolution profile with multiple time points in multimedia is
recommended.
In the case of low solubility/high permeability drugs (case 2), drug dissolution may be the rate
limiting step for drug absorption and an IVIVC may be expected. A dissolution profile in multiple
media is recommended for drug products in this category.

Answer / manas

since body consist of different mediums,we perfom disso test in different media to make sure which media is suitable for a specific entity(drug) to give a maximum dissolution disso graph/value.
Taking into acccount of a new drug formulation when we are not sure about the media to perform disso or not specified in OGD,so multi-media disso is recommended to make sure of the disso media for a drug.

Answer / rajaguru

Human is body constitute more chemicals that using multimedia
Water 0.1N Hcl,0.01N Hcl ,PH 4.5 acetate buffer PH 6.8 phosphate buffer this are the multimedia check drug releaseis different media or not

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