Answer / rajendra gaikawad

I think , our body constitute various chemical compounds i.e HCL , Phosphate buffer,acetate buffer.
Hence when we make any new product,whether that product release the drug in these different medium or not.
Since sometimes the site of action is different and whether our drug will release the drug in other medium or not.
Hence to ckeck drug release other than stomach multimedia dissolution profiling is done.

Answer / sandeep singh

If the dissolution is slower
than gastric emptying, a dissolution profile with multiple time points in multimedia is
recommended.
In the case of low solubility/high permeability drugs (case 2), drug dissolution may be the rate
limiting step for drug absorption and an IVIVC may be expected. A dissolution profile in multiple
media is recommended for drug products in this category.

Answer / manas

since body consist of different mediums,we perfom disso test in different media to make sure which media is suitable for a specific entity(drug) to give a maximum dissolution disso graph/value.
Taking into acccount of a new drug formulation when we are not sure about the media to perform disso or not specified in OGD,so multi-media disso is recommended to make sure of the disso media for a drug.

Answer / rajaguru

Human is body constitute more chemicals that using multimedia
Water 0.1N Hcl,0.01N Hcl ,PH 4.5 acetate buffer PH 6.8 phosphate buffer this are the multimedia check drug releaseis different media or not

which functional group we can detect in IR?

3 Answers  

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What is discriminating media? How can u justify/select that which media (pH etc...)is suitable for your dissolution study of your compound?

5 Answers   Natco, SUN,

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What are modes of quantification in related substances

0 Answers   Hospira,

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What are the tests used in Hplc?Name any two.

4 Answers   Laurus,

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what is the difference between the Purity and Potency of drug substance

1 Answers   Divis Laboratories, Graviti Pharmaceuticals,

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what is the defination of accuracy & presicion?

8 Answers   Amneal Pharmaceuticals, GSK,

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why does the result variation in hplc and gc with same sample ?

4 Answers   Matrix,

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why we can use only 4 and 7 and 9 buffers in pH calibration

1 Answers   Chola, Cipla,

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why base line not starts from zero in gc?

1 Answers   Aurobindo, FDC, Reddy Labs,

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why we are used 4,7,9,2 buffers for the ph calibration

4 Answers   Aurobindo, Enaltec Labs,

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What is the difference between the optics of UV and PDA Detectors ?

3 Answers   Emmennar, Neuland,

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what is %labelled amount in content uniformity of dosage unit and its calculation?

0 Answers   Zydus Cadila,

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