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Why perform dissolution multimedia study in dissolution
Development
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Answer Posted / sandeep singh
If the dissolution is slower
than gastric emptying, a dissolution profile with multiple time points in multimedia is
recommended.
In the case of low solubility/high permeability drugs (case 2), drug dissolution may be the rate
limiting step for drug absorption and an IVIVC may be expected. A dissolution profile in multiple
media is recommended for drug products in this category.
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