Answer Posted / rajendra gaikawad

I think , our body constitute various chemical compounds i.e HCL , Phosphate buffer,acetate buffer.
Hence when we make any new product,whether that product release the drug in these different medium or not.
Since sometimes the site of action is different and whether our drug will release the drug in other medium or not.
Hence to ckeck drug release other than stomach multimedia dissolution profiling is done.

For standardization of volumetric solutions, acceptance limit for concentration is considered as 10% of nominal concentration and %RSD as NMT 0.2% (for appropriate no. of replicates). But , if %RSD has not met, what should be further action?

1959

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Please give idea about method development for cleaning method and how maco level establish

790

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Hi sir if any product monograph not given known impurities (may be 5 impurities) specifications then how we require to proceed for inhouse formulation?

755

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what is the procedure for cleaning of lenses of hatr accesory of ftir instrument?

2338

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what is the extinction coefficient for Indomethacin or at 319nm wave length.

4125

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How can we calculate "confidence interval" in analytical method validation? Pl. explain with example.

4365

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Please tell me about the pH of Polycaboxylic ether is it in the 5-6 range ever or more than 6

2650

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What is delay volume?

1432

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1.What is the difference between method validation and method verification 2.Which guidelines proposed to method transfer

1900

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is it nessesary to do solution stability for 7 days?

816

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Which parameters require to do in tech transfer?

817

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what is procedure of actual procedure for registration of drug?

2055

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If combination product how require to identify which imp is of which api?

864

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If we do accuracy at same concentration at which linearity planned,what is the need to do linearity separately?

2345

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process of Diclofenac sodium,IP.

2284

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