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how do you established the RRF for unknown impurity
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Answer / anjaneyulu
First we find response factor
response factor of impurity
=concentration of sample/area of impurity
RRF for unknown impurity is
=response factor of impurity/area of main peak.
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Answer / ks kumar
IS RRF Relative Response Factor or Relative Retention
Factor? , please mention in detail
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Answer / gangadhar
Method-l:
RF of impurity=peak area of impurity/Conc.of impurity.
RF of analyte=peak area of analyte/Conc.of analyte.
RRF of impurity=RF of impurity/RF of analyte.
Method-ll:By linearity method.
RRF of impurity: slope of impurity/slope of analyte.
RRF correction:%impurity/RRF.
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Answer / babasaheb gilbile
RRF calculation required same cons for impurity and main compounds solution. with help of HPLC this solution measured area response for Impurity and Main peak.
Then calculated RRF= Area response of Impurity/ Area response of Main peak
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Answer / pramod br
Relative Response Factor (RRF) is an analytical parameter used in chromatographic procedures to control impurities/degradants in drug substance and drug product.
RRF is used to correct the difference in detector response of impurities with analyte peak. RRF is established by the slope method with linear range of solutions (usually +/-50% of the specification level).
RRF= Slope of impurity / Slope of analyte.
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