how do you established the RRF for unknown impurity
Answer Posted / gangadhar
Method-l:
RF of impurity=peak area of impurity/Conc.of impurity.
RF of analyte=peak area of analyte/Conc.of analyte.
RRF of impurity=RF of impurity/RF of analyte.
Method-ll:By linearity method.
RRF of impurity: slope of impurity/slope of analyte.
RRF correction:%impurity/RRF.
| Is This Answer Correct ? | 0 Yes | 0 No |
Post New Answer View All Answers
In which situation we require to prepare the standard solution from sample in Related substance method?
What is similarity factor?
about method developement in hplc
what is the difference between potentiometric titration and karl fischer titration?
Why irmoisture balance is used for corrugated box moisture testing
what is partion and column chromatography
Many times I don't got a caffeine peak in calibration of hplc using guard column ❓
What is the acceptance criteria for moisture balance when calibrated with sodium sulfate
why we use a particular hplc column for a particular compound give reasons?please
in dissolution why pool sample needed? in which type of drug pool sample need?
what is mean by nitrosamine impurities?
for heavy metal test lead used in which form pure form or any other form for preparation of lead standard sol
In rs method development when we are going area normalization method to dilute standard method?
How we choose the mobile phase for method development.?
How they found 1mL of K.F reagent is equivalent to 5mg of water and if we change the composition of K.F reagent, is it can neutralize more amount of water?