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what is peak purity ??
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Answer / ch.h.n.prasad reddy
Peak purity in HPLC is nothing but SPECTRUL PURITY not
Chemical purity. In HPLC Each peak is combination of many
data points. Each data point is having SPECTRUM. In peak
purity calculation each data point SPECTRUM is compared
with SPECTRUM of Peak apex Data point. In this we can
compare deferent region data points with Peak apex Data
point SPECTRUM. At that time we consider Base line noise,
Solvent noise etc.... we can select wave length range
also....
Always Purity angle is less than threshold then only Peak
Purity can pass.
Best Example: Isomers
Both isomers can show same spectrum but chemically they
are different. In this case if we get single peak also our
Peak Purity can Pass because our Peak apex Data point
SPECTRUM and deferent regions in that Peak data points
SPECTRUM is SAME.
Thanks
CH.H.N.PRASAD REDDY
RESEARCH SCIENTIST
prasadreddy19@gmail.com
| Is This Answer Correct ? | 104 Yes | 10 No |
Answer / saran
In PDA Detector, Purity angle value is less than the threshold
| Is This Answer Correct ? | 48 Yes | 14 No |
Answer / umesh patel
IT IS DEFINED AS PURITY OF A PERTICULAR PEAK THAT IT IS NOT
COELUTED WITH OTHER IMPURITIES
PURITY=RATIO OF ABSORBANCE B/W THE ROOT OF UP SLOPE AND
APEX/RATIO OF ABSORBANCE B/W THE ROOT OF DOWN SLOPE AND APEX
IF THE PURITY=1, PURE PEAK
| Is This Answer Correct ? | 51 Yes | 20 No |
Answer / ramakrishna
to identify whether the particular peak is single or
combination of peaks.
if angle is less than threshold the peak is pure.
if angle is more than threshold the peak is impure.
| Is This Answer Correct ? | 36 Yes | 14 No |
Answer / g.venkata suresh
Peak purity is nothing but purity angel should be less than purity threshould
Purity angel is a measure of the spectrul hetrogeneity of the peak based on the spectrum overall the peak using spectrum constract angel.
Spectral constract angel is defined as the shape difference between two spectra.
Purity threshould is a minimum purity of the reference standard in the formulation.
| Is This Answer Correct ? | 1 Yes | 2 No |
Answer / rashid ansari
Dilute o.1 ml phosphoric acid to 100 ml with water
| Is This Answer Correct ? | 0 Yes | 2 No |
Answer / kuchela rao athota
spectra are used to calculate the purity level of the peak,
or to construct the similar curves.
Similarity/Threshold
Ln(Similarity)
Similairty/Threshold ratio
| Is This Answer Correct ? | 15 Yes | 19 No |
Answer / jilani
Peak purity means 100% purity of drug. SPECTRUL PURITY not
Chemical purity.
| Is This Answer Correct ? | 3 Yes | 9 No |
Answer / anil kumar
Peak purity we have to check through the PDA detector. It
should be NLT99%.Peak purity we can check in 3D from uv to
visible range.
| Is This Answer Correct ? | 15 Yes | 32 No |
Answer / ganesh bhavar
peak purity means 100% pure peak of drug
| Is This Answer Correct ? | 10 Yes | 41 No |
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