Analytical Chemistry Interview Questions
Questions Answers Views Company eMail

Difference between uv detector nd RI DETECTOR? wt s the difference between OVI Solvents nd residual solvents incase of GAS CHROMATOGRAPHY? nd wt s its detection limit?

3 11002

on what basis SOP's can be changed? IF mobile phase ratio is 70:30 to how much % can we change the ratio in HPLC process

Cipla, Ranbaxy,

7 11119

Why caffeine as a reference standard used for calibration of HPLC?

Orchid, Gangwal Chemicals,

11 42717




What is the composition of K.F

IPQA,

6 33780

What should be the precision for HPLC during technology transfer?

3 6296

how do start hplc method development? how much sample required for developing the method development?

BMS, Indoco Remedies, Sun Pharma, Cipla,

3 41136

Wt s the use of linearity in HPLC method validation

4 11332

which pharmacopeoia mentions that caffiene is used as a standard for HPLC calibration? which other standardscan be used for the same?

Hetero, Mylan,

1 5458




Why will a solution of aspirin without acid or basic hydrolysis give yellow colour with a solution of Ferric chloride?

1 3647

Why do we use 0.005M h2so4 solution for preparation of k2cr2o7 solution for UV calibration?

Medreich, Jubilant, Mylan,

3 19427

In HPLC what is Single point threshold, peak purity index and minimum peak purity index? what should be consider for pure peak.

3 22048

why the sucrose used in calibration of polarimeter

Neuland,

5 11128

what r the parts calibrated in gc

Reddy Labs, ELBS,

21 21491

acceptance criteria for ph meter, hplc detector,pump,injector,oven when we calibrate.

3 18725

is there any material other than caffene to calibrate hplc detector

Biocon,

12 17505


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Un-Answered Questions { Analytical Chemistry }

How can the GC or HPLC method is selected to determine the impurity profile in drug product?

5387


why sre you used Potassium hydrogen phthalate in standarisation of 1N NaOH and 0.1 N Perchloric Acid?

6766


What is AV value in test uniformity content ,describe calculation

127


Why we check moisture,ash & AIA in product

456


can we use the same detector in HPLC as well GC and what could be the differences we can find in the final chromato graph in any aspects?

896






2. Two grams of Benzoic acid are dissolved in 200 ml of water and extracted with 200 ml of diethyl ether. The distribution coefficient of benzoic acid is 100, and its dissociation constant is 6.5 10-5. Calculate the distribution ratio (D) of benzoic acid at pH 2, 5, and 6. 3. Calculate D at pH 2 to 10 (1 unit apart) in the above problem, and plot D versus pH.

862


using gradient pressure in gas chromatography are not ?using gradient pressure why

2104


Why to use propyl paraben in HPLC gradient calibration

446


1)What's the meaning of Absorption,give a example. 2)What's the meaning of Adsorption,give a example. 2)what is the difference between Absorption and Adsorption.

1104


why disodium tartarate used in karl-fischer instrument ?.

688


What are the primary considerations in extractables and Leachables ?

989


In HPLC (Waters) software Empower1,2 &3 what is the updation for each version

1390


For limit test of heavy metals in BP, Method C require that the substance is ignited at a temperature not exceeding 800 °C. Why confines such the temperature?

2413


what is the purge flow & how to calculate

1159


How can we calculate offset value pH measurment

185