Analytical Chemistry Interview Questions, Answers for Freshers and Experienced asked in various Company Job Interviews

Analytical Chemistry Interview Questions

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inhouse product is in capsule form in combination and RLD is in tablet form then can we proceed for multimedia CDP? in inhouse capsule product disso is paddle with sinker in release media is there then RLD product in tablet form then with same as paddle with sinker we can proceed n.a.?

687

Ph meter can show more than 14 ph reading? Why ph range in between 1 to 14 only?

713

How to set specification of assay, fisdolution and related substances?

846

how to qualify the impurity?

808

what is the acceptance criteria for enteric coated tablets in 0.1n hcl validation in each parameter?

861

What is the formula for relative diffrence for standard solution in solution stability in validation?

766

How require to perform linearity as per ANVISA? What are the acceptance criteria?

1292

[3/30, 13:29] Manoj P Venkatpurwar: How hplc column selection according to structure? How mobile phase buffer selection on molecule structure?

726

in DMF having extra impurities and in api COA also having extra imp than USP or BP product then how require to proceed?

794

we can use expired sample for validation and analyst qualification?

777

If vendor having more imp than monograph then how to proceed? and how to set spec?

880

If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately

823

how require to set assay concentration for standard and sample?

886

What is dose dumping? why require to do?

898

Please give idea about method development for cleaning method and how maco level establish

713

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Un-Answered Questions { Analytical Chemistry }

what is the extinction coefficient for Indomethacin or at 319nm wave length.

4021

How to choose the which salt is suitable for mobilephase

3205

We use hicrome 10 cxs column in hplc analysis....pls tell me.. what is the meaning of 10 cxs?

1698

In rs method development when we are going area normalization method to dilute standard method?

1492

What is rs test why we are performing rs test?

1823

if your impurity coeluting with each other in that situation how require to set specification? is it acceptable?

931

for inorganic molecules require to do RS, Assay and disso?

704

2284

Why sometime potassium ortho phosphate mix with acetone use for sample preparation for hplc

1439

some product having water content method with pyridine and ethylene glycol mixture instead of methanol? how they are selecting and methanol is not suitable solvent how ?

2620

from where i get mortar pastle for glass bottle crush? it's required for testing of it?

2244

what is difference between UV - VISIBLE MODEL NO like 1600,1601,1700 etc ? plz explain me

2650

CAN WE DETERMINE THE PEAK PURITY IN GAS CHROMATOGRAPHY ANALYSIS?

1170

in each media we require to use SLS? how to proceed?

743

how you establish the LOQ?

744

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