Answer / hanimi

Before conclusion we have to review the data. investigation
has to done on test method and on experiment.
if there is no problem in experiment. It may have two
reasons
1. Analytical method is not suitable to get the the
consistant results
2. Sample is not uniform

Answer / reet

there may be any one of the reasons:
1. Air bubble in the injector needle (needle wash 2-3 times0
2. carry over might be there.
3. random variation in the flow rate
4. Integration problem (chk the processing method)
5. Sample itself may a problem !
i. solubility issues
ii.sample(generally proteins may be sticking to the
walls of the sample vial and also may be getting
irreversibly stuck on the surface of the column)
iii. temperature change.

Answer / sri krishna

Analytical method may not be good.

What is difference between NDA & ANDA ?

1 Answers   Alembic,

---

what are risk assement in the analytical qbd?

0 Answers  

---

what is peak purity? how may types of methods to determine peak purity?

3 Answers   Mylan,

---

what is use in calibration of conductivitimeter?

1 Answers   Claris Lifesciences, SRF,

---

principle of UV , PDA , RI detector in HPLC

0 Answers   Dr Reddys,

---

HOw do i calculate the number of theoretical plate on a HPLC chromatography

2 Answers   Laurus,

---

how you determine moist.of NaOH sol or NaOH flacks

0 Answers  

---

Why do we use sodium salicylate for Calibration TLC Cabinet U.V Lamps

3 Answers   Matrix, Spar Labs,

---

Why chromic acid wash is not recommended by USP for glassware cleaning?

1 Answers   Lupin,

---

reasons for negative peaks in chromatography

5 Answers   DRL,

---

What is the difference of time between two consecutive injections in HPLC?

2 Answers   Nectar Lifesciences,

---

Why do we use 500ppb sucrose and 500ppb 1,4 benzoquinone in TOC calibration?

2 Answers   Vardhman,

---