Analytical Chemistry Interview Questions
Questions Answers Views Company eMail

What is the difference between potentiometry assay and HPLc assay?

Apotex, Torrent Power, Aurobindo, Divis Laboratories,

2 11631

how std. of znso4

1 2672

Which std. used for standrdisation of ZnSO4?

988




In GC and HPLC ,how we can decide which of following method will be suitable or use for quantitation of chromatogram at the time of method development. 1.Area Normalisation 2.External standard method 3.Internal standard method

Atul,

1 4496

In Stability testing if significant change occurs then what will be the action plan?

Cipla,

2 7571

what is mean by profiling of dissolution

1 5318

How decided 10 ppm standard solution in Swab, rinse method.?

1 5714

WHAT IS THE LIQUID PHASE IN DB-624 COLUMN IN GCHS

3 5867




In capadity factor formula is K'= (RT of main compound/RT of first eluted peak)-1 in this formula what is 1

Piramal Healthcare,

1 4595

WHICH STANDARD WE USE IN SILICA ANALYSIS IN SILICA-GEL METHOD FOR SOLID SAMPLE

812

Why we inject a standard 6 times for Related substances by HPLC and 5 times for Assay?

GVK,

3 12191

In HPLC (Waters) software Empower1,2 &3 what is the updation for each version

APL,

1343

hii, i'm had a sample of 1L that gone through extraction & evaporation. i used 0.5ml of methanol for reconstitution before injecting the sample to HPLC. i made a calibration curve using a standard solution but now i'm confused about how to display the concentration i got from the sample. for ex. i got 0.2ug/ml how i'm gonna explane this is for the 1L ? please help .. i'll really appreciate it thanks

1 2180

Dear Sir, This is Thirunavukkarasu am working in Ordain Health Care AR&D, Am Having one problem While doing method development my question Metadoxine and Pyridoxine same chemical nature and structural activity i tried lot of methods but Analyte eluted same Retantion time i cant separate both peaks. solubility, pH both are same only only difference melting point metadoxine 210 C Pyridoxine 102 C please do the help needful for me

Ordain Solutions,

5 5212

some product having water content method with pyridine and ethylene glycol mixture instead of methanol? how they are selecting and methanol is not suitable solvent how ?

Micro Labs, VMSRF,

1106


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Un-Answered Questions { Analytical Chemistry }

How can we confirm the HPLC column is end-capped or not? Is it possible to identify by physical appearance?

1782


USP methodology, EP methodology, IP methodology, among three if possible to use one methodology for qualify working standard to use USP, EP, IP ? Please explain...

505


2. Two grams of Benzoic acid are dissolved in 200 ml of water and extracted with 200 ml of diethyl ether. The distribution coefficient of benzoic acid is 100, and its dissociation constant is 6.5 10-5. Calculate the distribution ratio (D) of benzoic acid at pH 2, 5, and 6. 3. Calculate D at pH 2 to 10 (1 unit apart) in the above problem, and plot D versus pH.

824


How can we determine Moisture content of HI?

1014


How can I develope method of dissolution by HPLC OR UV

923






how to select short coloum and long coloumn for new molecule

953


What is the purpose of octyl silane columns?

2509


what is the procedure for cleaning of lenses of hatr accesory of ftir instrument?

1020


How can we calculate offset value pH measurment

150


What are modes of quantification in related substances

840


What is the difference between BD

704


Why irmoisture balance is used for corrugated box moisture testing

999


using gradient pressure in gas chromatography are not ?using gradient pressure why

2076


what is weight veriation in pharma industry ? plz explain me

986


In GC calibration,what is the procedure to calibrate the TCD (thermal counductivity detector)suggest ?

1872