Analytical Chemistry Interview Questions
Questions Answers Views Company eMail

What is the principle of GC/HPLC ?

BioCan, Biocon, Megafine Pharma,

4 45676

Why pH Range has been fixed as 0 to 14 ?

Matrix, Akums, Cipla, SUN,

1 4157

How you develop a method in HPLC?

Wockhardt, Perrigo, CU,


why using buffers in hplc inteed of water

5 8095

How long we can use hygroscopic reference standard in terms of water absorb.I mean in line with respective monograph's specification or more than that?

1 1154

Why we use methy Ethyl Propylparabine For HPLC Calibration

1 3165

What is use of LOD and LOQ in validtion and give range and in calculation why we use 3.3* LOD here why we use 3.3

Reddy Labs, Dr Reddys, IPCA,

1 2769

In specificity what parametrs are consider why that parametrs

2 3710

ash or residue in that what will be there.

2 3028

How can we determine Moisture content of HI?

Cipla, Reddy Labs,


What is difference between oos


7 20299

what is the differance between Analytical and semi micro balance?

2 9008

In the method validation proceedure,lod & loq calculation we use the formulae for LOD=3.3*SD/slope and for LOQ=10*SD/slope,why we use 3.3 & 10 in the formulae?

1 8047

In HPLC Chromatographic separation Resolution equation is Rs = 1.18 (tR2 –tR1)/wh1+Wh2, Where, tR2 and tR1 is run time of eluent ratios of the distances from the point of application to the centers of the spots and the distance travelled by the solvent front from the point of application (retardation factor), and Wh1and Wh2 , is peak width of at half height. What is 1.18 ?

1 3205

what is mean by theoritical plates(not formula) ?

Micro Labs,

4 9823

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Un-Answered Questions { Analytical Chemistry }

why we are using benzene, anyline in acetic anhdride assay titration method?


Describe your field experience sample type collected,sample techniques,field measurements taken and equipment used?


What is FFA, PV, and PAV value in oil.


How to define samples weight in moisture content


what is the limit for KF Factor ,we take factor using water we will found factor between 6 to 7 ,while on KF Reagent bottle mentioned 5 mg/ml water content.if we not use dried methanol it is effect on factor.


process of Diclofenac sodium,IP.


what is the importence and role of LCMS and LCMS/MS and their applications? which type of compounds are analysis by lcms?


What is column in chromatography?


what is the extinction coefficient for Indomethacin or at 319nm wave length.


what is the principle involved in turbidometry and nephelometry ?


Basic principle of ESI?


2. Two grams of Benzoic acid are dissolved in 200 ml of water and extracted with 200 ml of diethyl ether. The distribution coefficient of benzoic acid is 100, and its dissociation constant is 6.5 10-5. Calculate the distribution ratio (D) of benzoic acid at pH 2, 5, and 6. 3. Calculate D at pH 2 to 10 (1 unit apart) in the above problem, and plot D versus pH.


Why a1% value is used for some product ? What is the criteria for selection a1% value ?


How to decide assay range for non pharmacopeial API analysis by HPLC? Could you give me any reference for same e.g Guidelines or Paper publications?


We use hicrome 10 cxs column in hplc analysis....pls tell me.. what is the meaning of 10 cxs?