What is use of LOD and LOQ in validtion and give range and in calculation why we use 3.3* LOD here why we use 3.3






What is use of LOD and LOQ in validtion and give range and in calculation why we use 3.3* LOD here w..

Answer / kovida

LOD and LOQ are the smallest amount of the particular compound that can by detected and quantiified by using the developed HPLC method.

The signal to noise ratio is that minimum amount which when injected in HPLC it gives minimum detectable peak area.

The value of amount at this point is multiplied by 3 to get LOD
and by 10 to get LOQ value. In short LOD is the thrice value of minimum value and LOQ is ten times of minimum value that can be injected in HPL

Is This Answer Correct ?    1 Yes 2 No

Post New Answer




More Analytical Chemistry Interview Questions

What is the lab normality??

3 Answers   DRL, Tagros,


IF HPLC CALIBRATION FAILED THEN WHAT YOU DO

6 Answers  


In Analytical method development related substance method when did follow w/w method when did follow area normalisation method

5 Answers  


WHAT IS DIFFERENCE B/W MALTINGRANG/DSC

0 Answers   Glochem,


water is more polar than acetonitrile.but in reverse phase chromatography peaks elute earlier when we increse Acetonitrile.what is the reason.

10 Answers   Matrix,






why has inject 5 injection in assay

2 Answers   Lupin,


What is the difference between BD

0 Answers  


Why PH range from 0to14.

2 Answers   Reddy Labs, College School Exams Tests, Wings Customer Care,


what is the procedure for cleaning of lenses of hatr accesory of ftir instrument?

0 Answers  


How will you convert a 6 Normal solution to 8 Normal solution?

16 Answers   Reddy Labs,


how can we decide the limit of cleaning validation? What is the criteria for it?

2 Answers   Glenmark,


Chromatographic Purity is a Qualitative analysis

2 Answers   Shasun Chemicals,






Categories
  • Organic Chemistry Interview Questions Organic Chemistry (285)
  • Inorganic Chemistry Interview Questions Inorganic Chemistry (113)
  • Analytical Chemistry Interview Questions Analytical Chemistry (1183)
  • Physical Chemistry Interview Questions Physical Chemistry (62)
  • General Chemistry Interview Questions General Chemistry (300)
  • Chemistry AllOther Interview Questions Chemistry AllOther (77)