In burette calibration of Karl fischer Instrument, the multiplication factor 1.00693 is using for how much ml of water dispenced. why
1 3323In UV-VIS spectrophotometer:My diluent is methanol even though i corrected base line for methanol,In my sample scan i found methanol peak.what is the reason?
2 9023What is the diffrence between the performing of LOD ordinary drying at voven and vaccum method.
Apex,
4 9153how a particular wavelength can be different for a particular compund while analysing by uv and by HPLC.
1827in hplc calibration we are using 0.05% acetone why we are using that one and what happen when its conc increases or decreases
4 29725what is the different in Total ash, sulphated ash, acid insoluble ash, alcoholic or non alcoholic ash?
9421Post New Analytical Chemistry Questions
how decide the clining method and cleaning method validation require for this perticular products?
In GC calibration,what is the procedure to calibrate the TCD (thermal counductivity detector)suggest ?
Ratio of Water and Acetonitrile(diluent) is not recommended to use in cleaning method validation,why?
What is shaking level in GC?
2. Two grams of Benzoic acid are dissolved in 200 ml of water and extracted with 200 ml of diethyl ether. The distribution coefficient of benzoic acid is 100, and its dissociation constant is 6.5 10-5. Calculate the distribution ratio (D) of benzoic acid at pH 2, 5, and 6. 3. Calculate D at pH 2 to 10 (1 unit apart) in the above problem, and plot D versus pH.
in monograph 7 imp are there but in vendor showing 5 imp do not req to include 2 imp for that what will be justification?
if identification threshold crosses the limits then what next step?
What is the formula for relative diffrence for standard solution in solution stability in validation?
If inhouse hplc related substance method is completly diffrent from Usp for finished proďuct with diffrent impurities then how require to prove method equivalecy?
Why we check moisture,ash & AIA in product
If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately
how require to set assay concentration for standard and sample?
Why we select scan range from higer wavelength to lower wavelength in uv visible spectroscopy and ftir spectroscopy ? .
Did anybody have method for acetyl cysteine effervescnce tablet
how require to select dissolution media? what is discrimination?
