Answer / ramakrishna- micro labs

In RS analysis we r analysed for impurity purpose,here we take
more concentration when compare to standard,that's why
standard area comes very less when compare to sample,so inject
standard 6 replicates the % RSD is NMT 5.0 , we give 5
replicates %RSD is NMT 2.0,the system suitability criteria
than more chances to pass for 6 replicates injections

Answer / laxman rapolu

In Related substances, we are preparing the standard in the
unknown impurity concentration level.This is the less
concentration.for consistency purpose we should
inject.Because we are quantifying impurities against diluted
standard.This is applicable to external standard method.

Dear sir, This is R.Kadambavadani working in a pharma industry. while doing RS analysis of ibuprofen API, unknown peak eluting some times in the 0.6 Min RT. Kindly send me what is the exact reason behind that. also am using ACN the mobile phase.

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