What is the reason for using the 900ml of dissolution medium
Answers were Sorted based on User's Feedback
Answer / kuldeep
bcz we test according to our body condition......and 900 ml is our stomach minimum capicity
Is This Answer Correct ? | 19 Yes | 29 No |
Answer / rahul kulkarni
If one see pharmaceutical reference books it is always
shown dissolution apparatus of 'one' jar only with a
stirrer (paddle/ basket) . So at the beginning of
pharmaceutics pharmacist used a glass jar (beaker) of
capacity 1 lit which is easily available in market.and to
avoid spillage from top they meight have used a little less
volume.(1000-100)=900 ml
Though our full stomach capacity ( of average person) is
approx. 900 ml in actual case after taking Tablet or
capsule we are not drinking 900 ml of water but vary 200
to 500 ml.
The habitual (traditional) 900 ml also refers the diluted
acidic media (0.1 N to 0.01 N) worst condition in stomach
where solubility margins are measured.
When a drug goes into solution the amount in % found
experimentally (ie: by instrumental methods-
Quantification by UV spectrophotometer/ By HPLC) So 900
ml mathematics fits any further dilution when the
readings are in working/ instrumental range
Is This Answer Correct ? | 4 Yes | 16 No |
Answer / janak patel
IN NORMAL HEALTHY VOLUNTEER THE GASTRIC FLUID CONTENT IN
STONMACH IS ABT 900 ML SO..
Is This Answer Correct ? | 5 Yes | 20 No |
how decide the clining method and cleaning method validation require for this perticular products?
Describe 5 components of SFC ?
1 Answers College School Exams Tests,
How to make up 100ml of a solution cintaining compound A at 95µg/ml and compound B at30µg/ml for an HPLC reference standard.
How we fix the validity period of a Normal solution and re-standardization due date
please explian me about area normalisation method,diluted standard method,impurity vs impurity and which one has to be selected in method development
wat is the role of michelson interferometer in FTIR and He-Ne lase.detailed answer required in simple language
what is the extinction coefficient for Indomethacin or at 319nm wave length.
0 Answers GSK GlaxoSmithKline,
column washing procedure for normal phase and reverse phase?
What is the reason for using the 900ml of dissolution medium
what is mean by 21 CFR PART? In that what is 21 ?
how to calculate elemental impurities?
What is Threshold in hplc?