How to determine the EDTA content by potentiometry
titration in Ceftriaxine sodium
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Answer / Sadanand Mishra
Determining EDTA content using potentiometric titration in Ceftriaxine sodium involves several steps and requires specific equipment like a pH meter, burette, and suitable indicator. Here's an overview:n
1. Dissolve the Ceftriaxine sodium sample in a suitable solvent (e.g., water) to make a known volume of solution.
2. Choose a suitable indicator for EDTA titration, such as methyl orange or bromothymol blue.
3. Titrate the sample solution with a standard EDTA solution while monitoring the pH change using a pH meter.
4. The equivalence point is reached when there's no further significant change in pH, indicating that all available EDTA has reacted.
5. Calculate the EDTA content in the Ceftriaxine sodium sample by comparing the volume of standard EDTA used to the known volume of your sample solution
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