What is the difference between Capillary column and Packed
column.
Answers were Sorted based on User's Feedback
Answer / alpesh patel
Capillary column : Stationary phase is coated with the
inner wall of the column & it is
having high lenghth and low internal
diameter.
Packed column : Stationary phase is directly coated in
the column & it is having short length
and high internal diameter.
Is This Answer Correct ? | 116 Yes | 17 No |
Answer / mohite vikas
Capillary column gives better performance as compaired to
pack colums
Is This Answer Correct ? | 61 Yes | 19 No |
Answer / balla reddy. p
Packed columns are more durable, has higher sample capacity
(Sample load) ,more phase selectivity, and has lower cost.
The disadvantages are larger amounts of bleed, smaller
number of theoretical plates/efficiency (i.e. separating
power for similar compounds is much low) and particle loss
into the detector. So it can not be coupled with MS or other
sensitive detectors.
Capillary columns have the advantage of larger theoretical
plate numbers /efficiency /higher resolution and inertness.
They excel at low ppm to ppt level analysis. They are
limited in phase selectivity options but their low carrier
gas use to the detector and low bleed characteristics allows
Mass Spectroscopy and other sensitive detectors to be used
effectively.
The use of bonded phases permits higher oven temperatures to
be used in applications.So capillary column withstand higher
column oven temperature compared of packed column.
Is This Answer Correct ? | 45 Yes | 4 No |
Answer / pharmainterview
Packed columns: Have high particale size silica (old)
Capilliary columns: Have low particle size silica (new)
Regards
pharmainterviewquestions.blogspot.in
Is This Answer Correct ? | 18 Yes | 3 No |
Answer / m m shaikh
Capilary columns:-1) Capillary columns gives high resolution ,Accuracy in analysis ,Rapid results than tha packed .
2)
This is bcoz of High lengh & low innr diametr.
It has 10- 100 meter lengh & 0.2 to 0.53 inner diametr.
3)This columns gives highr theoratical platea,inertness.to samples.
4)packed columns have low length & high id.
Is This Answer Correct ? | 12 Yes | 0 No |
Answer / swapnil borse
Packed columns have higher sample capacity than capillary
columns, although the difference has been greatly reduced by
the large-bore 530µm capillaries invented by Agilent.
Improvements in detector sensitivity have also reduced the
need for large samples. The one area in which packed columns
may have an advantage is in analysis of gas samples.
For almost all other samples, capillaries provide much
better efficiency (narrow peaks) which leads to greatly
improved peak separation. In fact, the separating power is
so great that many analyses can be done on surprisingly
short columns in very brief runs. This time saving
translates directly into reduced turnaround time and
increased sample throughput.
For new or updated methods, we recommend capillary columns
unless there is some overwhelming reason for using packed
columns.
Is This Answer Correct ? | 14 Yes | 9 No |
Answer / ksreddy
capillary column does nothaving any stationary phase. its
contain length and diameter.it is used for only back
pressure in system calibration.
packed column :its contain stationary phase.
Is This Answer Correct ? | 13 Yes | 65 No |
why peak purity not considered in GC?
4 Answers DRL, Reddy Labs, Vimta Labs,
What is split
what is DIPE limit in residual solvent?
Dear sir, This is R.Kadambavadani working in a pharma industry. while doing RS analysis of ibuprofen API, unknown peak eluting some times in the 0.6 Min RT. Kindly send me what is the exact reason behind that. also am using ACN the mobile phase.
what is the difference between polarimeter lamp and ir lamp
Why do we use 500ppb sucrose and 500ppb 1,4 benzoquinone in TOC calibration?
defination of wavelength & wave number
WHY POTASSIUM DICROMATE USING IN UV CALIBRATION
1 Answers Apotex, Micro Labs, Rene,
ash or residue in that what will be there.
what are the important specifications for a Column ?
What is the difference between Spectroscopy and spectrophotometry,What are the applications?
4 Answers Caplin Point, Cipla,
what type of compounds do we see lod @ wat type compounds do we see m.c