Why sodium hydroxide used for maintain pH of phosphate buffer
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Answer / Vijay Singh Yadav
Sodium hydroxide (NaOH) is a strong base that can be used to adjust the pH of a phosphate buffer. In a phosphate buffer, hydrogen ions (H+) are bound to phosphate anions (HPO4^2- and H2PO4^-). If the solution becomes too acidic (an excess of H+), sodium hydroxide can be added to neutralize some of the hydrogen ions, thus increasing the pH. Conversely, if the solution becomes too basic (a deficiency of H+), hydrochloric acid or another weak acid can be added, and sodium hydroxide can be used to counteract this by providing additional hydroxide ions (OH-), which react with the acid to form water and free hydrogen ions, thereby decreasing the pH.
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