Why we more noise in PDA detector compared to UV detector?
Answer / anil
There is no Integration function in the conventional UV-Vis spectrophotometer which
accumulates the signal. For example, the total required time will be 1000 sec. for 1000 data
points and it takes 1 sec. to measure one datum. In this case, all 1000 data have the same signal
to noise ratio (S/N).
But in a PDA instrument which has a 1000 photodiode array, 1000 data points can be
measured in 1 sec. and it would take 1/1000 sec. to achieve the same result obtainable in 1 sec.
in a conventional instrument. Therefore, when the same sample is measured for 1000 sec in a
PDA instrument, the signal is accumulated and is 1000 times greater than when measuring for 1
sec. The noise will be 10001/2
. This means that the S/N ratio is improved by 10001/2
.
This resulting benefit of fast data acquisition is termed Felgett’s S/N Advantage or
Multichannel Advantage
Is This Answer Correct ? | 10 Yes | 1 No |
which brands HPLC COLUMN available in market
From peak purity spectrum, where or at which point peak purity angle & purity threshold is checked?
Difference between related substances & impurities
Hi sir if any product monograph not given known impurities (may be 5 impurities) specifications then how we require to proceed for inhouse formulation?
what is the diffrence between absorbance and absorption in the beer,s lamber formula ?
Basic principle of ESI?
Why dissolution test is not performed in all of the products
How do we quantify crystaline and amarpous forms by using (NMR, XRD)spectroscopic techniques? Which any others instruments are useful for this quantification? explain
0 Answers Graviti Pharmaceuticals, Vimta Labs,
What is difference between Potency & purity
What is Temperature ?
what are the guidelines for analytical method validations?
why wetlab is called as wetlab