Why we more noise in PDA detector compared to UV detector?
- 1 Answers
- 10653 Views
- Aurobindo, I also Faced
- E-Mail Answers
Answer Posted / anil
There is no Integration function in the conventional UV-Vis spectrophotometer which
accumulates the signal. For example, the total required time will be 1000 sec. for 1000 data
points and it takes 1 sec. to measure one datum. In this case, all 1000 data have the same signal
to noise ratio (S/N).
But in a PDA instrument which has a 1000 photodiode array, 1000 data points can be
measured in 1 sec. and it would take 1/1000 sec. to achieve the same result obtainable in 1 sec.
in a conventional instrument. Therefore, when the same sample is measured for 1000 sec in a
PDA instrument, the signal is accumulated and is 1000 times greater than when measuring for 1
sec. The noise will be 10001/2
. This means that the S/N ratio is improved by 10001/2
.
This resulting benefit of fast data acquisition is termed Felgett’s S/N Advantage or
Multichannel Advantage
| Is This Answer Correct ? | 10 Yes | 1 No |
Post New Answer View All Answers
What is the requirement for brazil in the analytical method vslidation comparr to ich?
How can I develope method of dissolution by HPLC OR UV
In the isomers,enantiomers give the only physical properties present such that no chemical properties present.
Why use only methanol,used determinationof moisture content not use other solvents
what is partion and column chromatography
What is the difference between Discriminating media and DPDM(Dissolution Profile with Different Media)
acceptance criteria for lod & loq by standard deviation of response and slope??
We use Potassium Dichromate solution for the calibration of UV-Visible Spectrophotometer in UV region. My question is to calibrate visible region which solution could be used in photometric accuracy
what parameters we will consider while developing a HPLC method and how we confirm our HPLC method is valid?
what is the principle of UV Vis spectroscopy, AAS, ICP OES,ICPAES, ICP-MS and FTIR
if instrument calibration fails then what require to do?
What is rs test why we are performing rs test?
what is the difference between potentiometric titration and karl fischer titration?
why require to do water content for drug product?
why octanol used to determine the partition coefficient ?
