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what is deference b/w the working standard and reference
standard
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Answer / tushar
Reference std is like USP,EP std , in this std we get COA
including results of Potency by HPLC , NMR & XRPD data.
whenever there is requirement of w.std preparation first we
have get API rawmaterial from warehouse & we check assay ,
water content or LOD & Related substances aganist reference
std . Some times we are doing analysis in duplicate & get
mean value.then we decide final assay or potency value &
it's validity one year
| Is This Answer Correct ? | 46 Yes | 3 No |
Answer / vipul patel
Reference standard is primary standard.they are provid by Pharmacopoeia (like USP,Phone.Eur.JP etc).they no need other Qualifications
Working standard is Secondary standard .they make by Reference standard. They need other Qualifications like Assy,RS,LOD,
| Is This Answer Correct ? | 4 Yes | 0 No |
Answer / suresh
The reference standard otherwise called as the primary
standard. It contains maximum % purity and minimum level
impurity.
Working standard can be prepared from reference standard at
various concentration by dilution.
| Is This Answer Correct ? | 6 Yes | 9 No |
Answer / minoo
as i know, we should measure the assay against refrence standards at least two times. in different days by different instruments. then we should calculate linearity and validity , if they are ok we can use the tested material as working standard.
| Is This Answer Correct ? | 3 Yes | 7 No |
what is definition of validation? which components are followed give detail?
I have compare C2H2-air and C2H2-N2O flame AAS on determination calcium. Both use same range of std to plot calibration curve. (2-6ppm) When i measure the sample with phosphate, KCl and LaCl, C2H2-N2O flame give false positive result, around 0.5ppm. When i measure the sample with phosphste, KCl and EDTA. C2H2-N2O flame also give 0.5ppm false positive. But both above mentioned sample would not give false positive when measured by C2H2-air flame. What is the reason?
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