Follow Our FB Page << >> for Daily Laughter. We Post Funny, Viral, Comedy Videos, Memes, Vines...

what is deference b/w the working standard and reference

Answers were Sorted based on User's Feedback

what is deference b/w the working standard and reference standard..

Answer / tushar

Reference std is like USP,EP std , in this std we get COA
including results of Potency by HPLC , NMR & XRPD data.
whenever there is requirement of w.std preparation first we
have get API rawmaterial from warehouse & we check assay ,
water content or LOD & Related substances aganist reference
std . Some times we are doing analysis in duplicate & get
mean value.then we decide final assay or potency value &
it's validity one year

Is This Answer Correct ?    46 Yes 3 No

what is deference b/w the working standard and reference standard..

Answer / vipul patel

Reference standard is primary standard.they are provid by Pharmacopoeia (like USP,Phone.Eur.JP etc).they no need other Qualifications
Working standard is Secondary standard .they make by Reference standard. They need other Qualifications like Assy,RS,LOD,

Is This Answer Correct ?    4 Yes 0 No

what is deference b/w the working standard and reference standard..

Answer / suresh

The reference standard otherwise called as the primary
standard. It contains maximum % purity and minimum level
Working standard can be prepared from reference standard at
various concentration by dilution.

Is This Answer Correct ?    6 Yes 9 No

what is deference b/w the working standard and reference standard..

Answer / minoo

as i know, we should measure the assay against refrence standards at least two times. in different days by different instruments. then we should calculate linearity and validity , if they are ok we can use the tested material as working standard.

Is This Answer Correct ?    3 Yes 7 No

Post New Answer

More Analytical Chemistry Interview Questions

Why we have to take 42gm of sodium hydroxide instead of 40gm for preparation of 1M Sodium hydroxide as per Pharmacopia? Whether it means the formula for calculating molarity was wrong? 

4 Answers   Claris Otsuka, Ranbaxy,

water is more polar than acetonitrile.but in reverse phase chromatography peaks elute earlier when we increse Acetonitrile.what is the reason.

10 Answers   Matrix,

Whya the need of Specificity to do in Analytical Method Validation ?

5 Answers   Dr Reddys,

who is the father modern liqiud chromatogrphy?

3 Answers   Amneal Pharmaceuticals, Car Chem, Cipla,

What are the different zones in stability according to ICH?

1 Answers   Apotex,

How did you conclude that when stressing a compond, all degradation products have eluted in chromatogram?

7 Answers   Matrix,

why require the ph, buffer during hplc mobile phase?

0 Answers  

Principle of single pan analytical balance

0 Answers   Amneal Pharmaceuticals, Bayer, Dr Reddys,

What is Endcapped Hplc column

2 Answers  


6 Answers   Glochem, Hetero,

why we are using hexane in calibration of number of drop per mL

0 Answers  

difference between pH & pOH ?

4 Answers  

  • Organic Chemistry Interview Questions Organic Chemistry (302)
  • Inorganic Chemistry Interview Questions Inorganic Chemistry (123)
  • Analytical Chemistry Interview Questions Analytical Chemistry (1385)
  • Physical Chemistry Interview Questions Physical Chemistry (62)
  • General Chemistry Interview Questions General Chemistry (478)
  • Chemistry AllOther Interview Questions Chemistry AllOther (190)