Analytical Chemistry Interview Questions
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In BP2013, Loperamid HCl monograph. Assay by titration with 0.1N sodium hydroxide using hydrocloric acid 0.01N and reading the volume added between the 2 points of inflexion. I have a question that if the diluent solvent is ethanol is certainly consumed a amount of volume of titrant, so this volume must be eliminated on the result calculation or not apart from first point which is subtracted above.

1587

If i performing one analysis on C8column then the same analysis done on C18 column then what will happen about Rt;Resulution;Peak shape Explain ?

1 5477

what is peak purity? how may types of methods to determine peak purity?

Mylan,

3 9948




why using Potentometry What Purpose? differance between manual and potentiometry? why using Some of materials in usig potentiometry? What is use of mericuric acetate in Potentiometry

Biocon,

1 2991

iam using ph instrument lab india make.3ponit and 5point.in calibration time 3point slope will come 98.89and 96.87.that limit is 85 to 105.what basis slope will come.any calucalation between them.5point wiicome slope 99.89?why 3p0int came 2 values

1 2999

iam usig ph buffers merk. manually how to prepare ?

969

Sulphated Ash incresed it will effect on product yield?

Biocon, Lupin,

2 2191

in loss on drying Why follows on constant weight not more than 0.5 mg, any region

Biocon,

1 9075




difference between selectivity and specificity

Troikaa Pharmaceuticals,

2 9865

when we talk about change in entropy we consider total entropy means of surround +entropy of system but when we talk about change in Gibss free energy we consider entropy of system.explain with reason.

ABC,

759

differnc btw c18 and c-8 column

Cipla,

3 9296

use of stry light

1 4766

when we have polar type of sample and solvnt hen which type of stationry phase we have to use

3 4242

what is motor rotation in case of sucrose

1 1735

why equlirium conatant of water have 14 value

GVK Biosciences,

896


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Un-Answered Questions { Analytical Chemistry }

How we performed the force degradation for drug substance, is any specific guideline is available for each parameter(Acidic, basic, oxidation,heat)? what conditions you mentained for above parameters.

1002


what is impurity profile. how to interpret this impurity profile to a drug product or drug substance.

1026


what is definition of validation? which components are followed give detail?

883


What are modes of quantification in related substances

869


why octanol used to determine the partition coefficient ?

952






In dissolution of tablets/capsules elaborate the Dissolution limit 20.0% to 60% Q in 30 minutes.

709


What is the main difference between ODS1 and ODS2 Hplc column.

1746


1.What is the difference between method validation and method verification 2.Which guidelines proposed to method transfer

212


function of detecter in hplc ,gc and spectroscopy? function of carrier gas in gc?

1186


How would you decide dissolution medium for NCE compound of class I drug

704


for heavy metal test lead used in which form pure form or any other form for preparation of lead standard sol

3556


why we use a particular hplc column for a particular compound give reasons?please

1490


WHAT IS THE PURPOSE WE USE HCL, CHOPPER, BURNER, MONOCHROMATOR in AAS? PLEASE EXPLAIN BRIEFLY

1045


how much mass should be there in volumetric flask while in preparation of sample for assay? 

1137


in gas chromatography what is the difference between gas flow rate and average linear velocity ?

990