Answer / samar mandal

In end capped column the no of free silanol groups are very less compared to non end capped column.A capping reagent like Cl(CH3)2SiCH3 is used to bond with the sillica bed apart from C8 and C18 group, which eventually block the free silanol group by forming silyl ether(-Si-O-Si-), which decreases the reaction between analyte and free silanol groups.

Answer / sagar flamingo ltd

In Case of End Cap Column both end are connected with SS Cap Which is easily removable.But In Case of without End Cap Column there are not having such type adjustment.

WHAT IS DIFFERENCE B/W MALTINGRANG/DSC

1 Answers   Glochem,

---

How to establish relative response factor for hplc. Why it is required?

0 Answers  

---

What is use of LOD and LOQ in validtion and give range and in calculation why we use 3.3* LOD here why we use 3.3

2 Answers   Dr Reddys, IPCA, Reddy Labs,

---

stability study is going on up to 3years for famotidine-USP but the pharmacopeia is revised and tlc test is replaced with hplc test. At the 4th year frequency the product is failed in hplc test .how can i assain the expiry or retest date and can i stop or continue the programme?

2 Answers   Nakoda Chemicals,

---

How can we separate Urea & semicarbazide in single HPLC method ?

2 Answers  

---

What is similarity factor?

0 Answers  

---

what is GLP? Which industries it requried?

1 Answers   Aurobindo, AXIS Clinicals, GVK,

---

If we have 120 minutes run time method for HPLC and you wan to decrease the Run time so what should you do??

6 Answers  

---

acceptance criteria for lod & loq by standard deviation of response and slope??

0 Answers  

---

What is the calibration procedure for Malvern MS2000 particle size analyzer and acceptance criteria?

2 Answers   Reddy Labs,

---

for which type of applications gas chromatography is used?

2 Answers  

---

At what distance the sample is collected in dissolution basket?

3 Answers  

---