How to develop the method when we have very low amount of
impurity?
- 2 Answers
- 7355 Views
- I also Faced
- E-Mail Answers
Answers were Sorted based on User's Feedback
Answer / kalpana
by doing the force degradation of the sample in different
condition(like acid, alkali, peroxide,thermal and
photolytic degradation)and then develope the method.
| Is This Answer Correct ? | 14 Yes | 2 No |
Answer / balaji
IN THIS CASE INCRESE SAMPLE CONCENTRATION EG; MY DRUG KNOW
IMPURITES LIMIT IS 0.05% UNKNOW IMP LIMIT IS 0.03% INTHIS
CASE STD PREPARATION IS 5MG/100 FURATHER 1/100 THIS IS KNOW
IMPURITES CONCENTRATION 3/100 AND 1/100 THIS UNKNOW IMP
MEANS API, SAMPLE CONCENTRATION IS 1MG/ML IF STD AREA IS
NOT COME INCRESE THE SAMLE CONCENTRTION MEANS
10/100*1/100*10/20*100=0.05% SAMLE CONCENTRATION IS 2MG/ML
| Is This Answer Correct ? | 1 Yes | 3 No |
If suppose 10 methods of dissolution given in pharmacopoeial for single content product then which method out of 10? or all 10 require to follow?
What r the limitatoins of uv visible spectroscopy ? Why Water use in blank standard for uv visible spectroscopy ?
in hplc chromatogram started from left to right and in uv spectrum started from left to right
solvents used in NMR
principle of FTIR
what is differance between density and specificgravaty
if rsd failed then what require to do?
what is mean by 40 in the dissolution basket mesh size?
What is mean by PDR?
How to Prepare Dilute Sodium hydroxide solution?
How can we calculates the solubility of the drug in different medias by injecting in to hplc????(solubility studies)
2 Answers Super Pharmaceuticals,
Can any one tell what is RECALL OF PROCEDURES is
Organic Chemistry 
