How to develop the method when we have very low amount of
impurity?
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Answer / kalpana
by doing the force degradation of the sample in different
condition(like acid, alkali, peroxide,thermal and
photolytic degradation)and then develope the method.
| Is This Answer Correct ? | 13 Yes | 2 No |
Answer / balaji
IN THIS CASE INCRESE SAMPLE CONCENTRATION EG; MY DRUG KNOW
IMPURITES LIMIT IS 0.05% UNKNOW IMP LIMIT IS 0.03% INTHIS
CASE STD PREPARATION IS 5MG/100 FURATHER 1/100 THIS IS KNOW
IMPURITES CONCENTRATION 3/100 AND 1/100 THIS UNKNOW IMP
MEANS API, SAMPLE CONCENTRATION IS 1MG/ML IF STD AREA IS
NOT COME INCRESE THE SAMLE CONCENTRTION MEANS
10/100*1/100*10/20*100=0.05% SAMLE CONCENTRATION IS 2MG/ML
| Is This Answer Correct ? | 1 Yes | 3 No |
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