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How to develop the method when we have very low amount of
impurity?

Answers were Sorted based on User's Feedback



How to develop the method when we have very low amount of impurity? ..

Answer / kalpana

by doing the force degradation of the sample in different
condition(like acid, alkali, peroxide,thermal and
photolytic degradation)and then develope the method.

Is This Answer Correct ?    13 Yes 2 No

How to develop the method when we have very low amount of impurity? ..

Answer / balaji

IN THIS CASE INCRESE SAMPLE CONCENTRATION EG; MY DRUG KNOW
IMPURITES LIMIT IS 0.05% UNKNOW IMP LIMIT IS 0.03% INTHIS
CASE STD PREPARATION IS 5MG/100 FURATHER 1/100 THIS IS KNOW
IMPURITES CONCENTRATION 3/100 AND 1/100 THIS UNKNOW IMP
MEANS API, SAMPLE CONCENTRATION IS 1MG/ML IF STD AREA IS
NOT COME INCRESE THE SAMLE CONCENTRTION MEANS
10/100*1/100*10/20*100=0.05% SAMLE CONCENTRATION IS 2MG/ML

Is This Answer Correct ?    1 Yes 3 No

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