Answer / mr.shoukatalli naikwade

API molecule without hydrocloride salts are in the form of
base and it is higly non polar.its solubility in water as
well as in our blood and gastric juices in stomach is very
poor.
Our pH of stomach is arround 2 and gastric acid consisting
mainly of hydrochloric acid 0.5%.

To increase API's solubility of drugs,salt formation plays
important role in dissolution and dis integration of tablet.

for salt formation hydrochloric acid is mostly choosed.

how you confirm the assay method?

0 Answers  

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why PH range 0-14 explain

5 Answers   DRL, Reddy Labs, Saint Gobain, Viva,

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why base line not start from zoro in GC Chromatograme.

1 Answers   Merck,

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What is the optimum period of storage of indicators?

1 Answers   Orchid Chemicals and Pharmaceuticals,

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When we r doing processing method for sst in Empower software by HPLC, What value has to give in void volume and as per which pharmacopia!

5 Answers   Micro Labs, Mylan,

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The boiling point of 1,3 butadiene is -4.4 DC & the boiling point of Pentane is 36.1 DC. Then how come Pentane elute before 1,3 BD in GC analysis?

1 Answers  

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How can we confirm the HPLC column is end-capped or not? Is it possible to identify by physical appearance?

0 Answers   JBCPL,

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What is the Deference between Bulk density & Tap density ?

2 Answers   Hikma Pharmaceuticals, Neuland, Reddy Labs,

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In chromatograpbic purity 90% is there, in assay 70% is there. How will you prove remaining 30%.

3 Answers   Dr Reddys,

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What is similarity factor and its use in api strength?

0 Answers  

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why do we have to used saturated ammonia in TLC

3 Answers   Cipla, IPCL, Mylan,

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what is internal standard define

2 Answers   Apex, Coromandel International Limited, Hikma Pharmaceuticals, IPCA,

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