Interested to Buy Any Domain ? << Click Here >> for more details...
why the most API molecule are in the hydrochloride form?
- 1 Answers
- 9707 Views
- I also Faced
- E-Mail Answers
Answer Posted / mr.shoukatalli naikwade
API molecule without hydrocloride salts are in the form of
base and it is higly non polar.its solubility in water as
well as in our blood and gastric juices in stomach is very
poor.
Our pH of stomach is arround 2 and gastric acid consisting
mainly of hydrochloric acid 0.5%.
To increase API's solubility of drugs,salt formation plays
important role in dissolution and dis integration of tablet.
for salt formation hydrochloric acid is mostly choosed.
| Is This Answer Correct ? | 27 Yes | 0 No |
Post New Answer View All Answers
What is the principle of HPLC, GC, LCMS, GCMS,LC QQQ, GC QQQ, LC Q TOF and GC Q TOF. What are the applications and Specificity?
For limit test of heavy metals in BP, Method C require that the substance is ignited at a temperature not exceeding 800 °C. Why confines such the temperature?
4. Describe the operation of the Craig apparatus. Chapter.3 Equilibrium Processes in Separations
Difference between the quantitative analysis and qualitative analysis?
Which parameters require to do in tech transfer?
What is a difference between potency and purity?
why does used dry caffien in HPLC calibration?
please explian me about area normalisation method,diluted standard method,impurity vs impurity and which one has to be selected in method development
using gradient pressure in gas chromatography are not ?using gradient pressure why
which are the sizes of capsules?
If inhouse hplc related substance method is completly diffrent from Usp for finished proďuct with diffrent impurities then how require to prove method equivalecy?
How will u perform degradation study in detectors other thann PDA in HPLC Methodology
why we use Dichlorobenzene.nitrobezine.t-butyldi sulhate.for calibration of gc Head space
If we do accuracy at same concentration at which linearity planned,what is the need to do linearity separately?
analytical method validation require to with respect to release specification or shelf life specification?
