in which situation require to take incident in validation?
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when we talk about change in entropy we consider total entropy means of surround +entropy of system but when we talk about change in Gibss free energy we consider entropy of system.explain with reason.
control of resolution in calibration of IR
in hplc calibration injector linearity pass,it means inj and det is good. why to perform detector linearity is it required, if it is required,what is difference between injector and detector linearity in hplc calibration
How you will select column for HPLC development depends on nature of compound and how it will work explain in brief?
How we can determine water content in piperazine
IS THERE ANY EQUIPMENT TO CHECK AND CALCULATE THE POLARITY OF A LIQUID?
How we choose the mobile phase for method development.?
Why 162 mg NaOH used for 1N volumetric solution in 150 ml water then 54.5 ml diluted with 1000 ml
Principle of HPLC in one sentance
In HPLC Chromatographic separation Resolution equation is Rs = 1.18 (tR2 –tR1)/wh1+Wh2, Where, tR2 and tR1 is run time of eluent ratios of the distances from the point of application to the centers of the spots and the distance travelled by the solvent front from the point of application (retardation factor), and Wh1and Wh2 , is peak width of at half height. What is 1.18 ?
How we performed the force degradation for drug substance, is any specific guideline is available for each parameter(Acidic, basic, oxidation,heat)? what conditions you mentained for above parameters.
Why pH range is 1-14 nt more than 14???
3 Answers IPCA, Lincoln Pharmaceuticals,
Organic Chemistry 
