gc Calibration % RSD failed what is the possible reasons?
Answers were Sorted based on User's Feedback
Answer / hiren
First is not column proper installations
Secound is not proper work syrring
Thred is injector septa so much punching
| Is This Answer Correct ? | 22 Yes | 0 No |
Answer / yogesh patel
flow rate of gas not proper its cose fluctuation in assay
| Is This Answer Correct ? | 5 Yes | 0 No |
Answer / alasyam ramesh
1) Improper stabilisation of column and system.
2) injector septa bleeding
3) partial blockage of detector jet.
4) syring struck due to solvents nature( solvent viscosity).
5) plunger moving and taking improper injection volume.
6) some time may effect room temperature also
| Is This Answer Correct ? | 5 Yes | 0 No |
If %RSD is failing in GC calibration means we have to check & replace following things,
1.Injector septa
2.glass wools in liner
3.syringe
Thanks,
B.Gangatharan.
| Is This Answer Correct ? | 4 Yes | 0 No |
why in GC calibration of linearity regression coefficient should not be less than 0.999
What is the pilot-plant in pharma sector.
What is similarity factor?
what is GLP? Which industries it requried?
1 Answers Aurobindo, AXIS Clinicals, GVK,
why has inject 6 injection in Releted compounds
why buffer is added in solvent system in HPLC ??
how to selecet an exact coloumn for an new molecule development by hplc how to select exact salt as buffer for new molecule development by hplc what is the the process to select the mode of saparation of compoundes by hplc what is the use of ph of buffer what is use of buffer,ph,organic phase,ans methods how the molecules get saparated in coloumn,
If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately
what is Fourier Transform
3 Answers Graviti Pharmaceuticals, GVK,
why we are performing residue on ignition?
in loss on drying Why follows on constant weight not more than 0.5 mg, any region
What is the diffeence between assay and uniformity of content