What is use of LOD and LOQ in validtion and give range and in calculation why we use 3.3* LOD here why we use 3.3
- 2 Answers
- 7074 Views
- Dr Reddys, IPCA, Reddy Labs, I also Faced
- E-Mail Answers
Answer Posted / nikkosthiru@gmail.corai12
LOD is Limit of detection. We can dedect the peak but cant quantify
LOQ Limit od quaantification. We quantify also this is known as reporting thereshold.
During the RS analysis Below LOQ level we cant included in the total impurities calculation.
LOD and LOQ Determination three methods
1.S/N Ratio method
3 or 2 ratio for LOD
NLT 10 ratio for LOQ
2. Slope Method
Plot the linearity for active and impurities through serial dilution at lower level
Formula for LOD
3.3*Slope/Std.dev
Formula for LOQ
10*Slope/Std.Dev
3. Visualization method
It will be using for only identification and TLC Method
| Is This Answer Correct ? | 1 Yes | 0 No |
Post New Answer View All Answers
what is the principle of UV Vis spectroscopy, AAS, ICP OES,ICPAES, ICP-MS and FTIR
What is the principle of HPLC, GC, LCMS, GCMS,LC QQQ, GC QQQ, LC Q TOF and GC Q TOF. What are the applications and Specificity?
what is the disso medium for tropsiun chloride
i want model written test paper for the post of analyst in IOCL(indian oil corporation ltd) any one pls help me
what is the extinction coefficient for Indomethacin or at 319nm wave length.
