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What factors contribute to the enthalpy change when a
denatured protein folds up?



What factors contribute to the enthalpy change when a denatured protein folds up?..

Answer / kurt heller

when the protein goes from unfolded to folded, it looses a
lot of entropy

the opposite reactions is:
each peptide bonds have 2 watermolecules bonded, they are
released

formation of hydrogenbonds contribute with some energy

the net result is that the folded protein has an energy,
which is 50 kJoule/mol lower than the unfolded state, and
this is practically independent of the size of the protein!

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