Why is buprenorphine less addictive than other opioids?



Why is buprenorphine less addictive than other opioids?..

Answer / Ratnakar

Buprenorphine is less addictive than other opioids due to its partial agonist activity and ceiling effect. Unlike full opioid agonists, buprenorphine only weakly activates the mu-opioid receptor, while also blocking the effects of other opioids. This means that even if a person takes more than the recommended dose, they will not experience a stronger effect, which can reduce the potential for addiction.

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