what is the difference in the aminoacid sequence in normal
haemoglobin and sickle cell anaemic person?
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Answer / raja
in human being normal haemoglobin differs from sickle
celled anaemic person in the sequence of aminoacids.
normal haemoglobin: val-his-leu-thr-pro-glu-glu-lys
sickle cell haemoglobin:val-his-leu-thr-pro-val-glu-lys
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Answer / naidu
normal haemoglobin amino acid sequence contains glu amino acid
but in sickelcell anaemia heamoglobin contains val residue
in the place of glu
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Answer / thulasi
nomal hb contains aminoacid glu in 6th position whereas in
sickle cell anemia it is replaced by valine.In sickle cell
anemia the hb is sickle shaped so it cannot carry oxygen as
it does normally.
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