please explian me about area normalisation method,diluted standard method,impurity vs impurity and which one has to be selected in method development207
How they found 1mL of K.F reagent is equivalent to 5mg of water and if we change the composition of K.F reagent, is it can neutralize more amount of water?195
How can we calculate offset value pH measurment83
What is stray light in uv what are units for stray light101
What are usp limits for theoritical plats,resoution,tailing factor,peak to valley ratio130
What are usp limits for total impurities,unknown impurity131
Why acetonitrile and water are used as extraction solvent when analysis melamine? I thought they are miscible and won't be able to separate...71
In HPLC calibration, caffeine is used as primary standard for wave length calibration due to caffeine is having dual maxima at 273 & 205 nm and one minima at 245 nm. Any body can give reference of these details from any pharmacopeia (with chapter no.) or any other authentic guideline?183
How to check hplc detecter sensitivity?106
What is the acceptance criteria for moisture balance when calibrated with sodium sulfate
What is diffrence between extractable volume and deliverable volume? Answer pls
pda detector mechanism?
what is the structure of DOWEX-50
Difference between hlaf and rlaf
iam usig ph buffers merk. manually how to prepare ?
in gas chromatography what is the difference between gas flow rate and average linear velocity ?
My question about gas chromatography sulfur chemiluminsecence detector. I test unknown sample gas by GC-SCD (calibrated ) and the result of *H2S is 279 PPM , *but when I test the same sample with the GC-TCD (calibrated ) the value of *H2S is 2500 PPM . I'd like to inform you that both GCs are calibrated and have very good operation conditions with stable parameters . the question is if the sample gas with higher H2S over detection limits of SCD detector (1000 ppm). why the result it 279 ppm Best regards
How do we quantify crystaline and amarpous forms by using (NMR, XRD)spectroscopic techniques? Which any others instruments are useful for this quantification? explain
During Validation study, Recovery is passing at all levels but Linearity is failing. Justify?
In BP2013, Loperamid HCl monograph. Assay by titration with 0.1N sodium hydroxide using hydrocloric acid 0.01N and reading the volume added between the 2 points of inflexion. I have a question that if the diluent solvent is ethanol is certainly consumed a amount of volume of titrant, so this volume must be eliminated on the result calculation or not apart from first point which is subtracted above.
what is DIPE limit in residual solvent?
why disodium tartarate used in karl-fischer instrument ?.
what is impurity profile. how to interpret this impurity profile to a drug product or drug substance.
How can we determine Moisture content of HI?