Interested to Buy Any Domain ? << Click Here >> for more details...
what is the difference between M.C and LOD
- 21 Answers
- 72968 Views
- Aurobindo, Cipla, Laurus, Matrix, Synthokem Labs, I also Faced
- E-Mail Answers
Answers were Sorted based on User's Feedback
Answer / ankalreddymsc
BY m.c WE CAN FINDOUT ONLY WATER CONTENT IN A DRUG
While trrough lod we can also know about non volatile
solvents present in a drug.
| Is This Answer Correct ? | 105 Yes | 25 No |
Answer / alpesh patel
M.C. result gives only water content present in substance
while LOD result gives water content+solvent present in
substance. Thus, LOD content is always hIgher than M.C.
| Is This Answer Correct ? | 91 Yes | 19 No |
Answer / i.kizar ahamed
MC gives only % of water in a substance(Low melting range
substance).But LOD result is a combination of water
content and other volatile organic solvents.And more over
Melting range of a substance has to be considered in case
of LOD. Substances whichever is having high melting point
is required for LOD checking.
| Is This Answer Correct ? | 56 Yes | 7 No |
Answer / amit patel
M.C =moisture content= the molecular water stored in the
molecule/it gives the exact water centent.(generally tested
by the KF titrator)
whereas
LOD=Loss on drying= unbound water + organic volatile
impurities.(in vacuum oven)
| Is This Answer Correct ? | 34 Yes | 3 No |
Answer / minal
Moisture content gives value of bound and unbound water
content while LOD gives value of unbound water plus non
volatile solvent content
| Is This Answer Correct ? | 25 Yes | 5 No |
Answer / s. jayapal reddy
M.C BY K.F:GIVES THE INFORMATION ABOUT INTRAMOLECULAR AND
EXTRAMOLECULAR WATER CONTENT OF THE MOLECULE.
L.O.D: GIVE THE INFORMATION ABOUT ORGANIC SOLVENTS AND
EXTRAMOLECULAR WATER CONTENT IN THE MOLECULE
| Is This Answer Correct ? | 15 Yes | 1 No |
Moisture content means how much water present in your
product or test sample
LOD Means how much non volatile solvents + water present
in your product or test sample
| Is This Answer Correct ? | 15 Yes | 5 No |
Answer / ss
Moisture content means how much water present in your
product or test sample
LOD Means how much volatile solvents + water present
in your product or test sample
| Is This Answer Correct ? | 10 Yes | 1 No |
Answer / swarupa kumar behera
M/c (moisture content) - It determine that how many quantity of water present in supplied sample. It generally check by Karlfisher.
LOD ( lose on Drying)- determine both water and non-volatile substance in supplied sample. It done in oven at 110'C for 1hr.
| Is This Answer Correct ? | 9 Yes | 2 No |
If we are getting split peak in Chromatogram,what we can do?
Through assay by hplc(anhydrous basis) product got 100.8% .How much the potency of that product.Moisture content is 1.7%,Sulfated ash is 0.02%,Total impurities are 0.3%
why we use polystyrene film for ftir calibration?
HOW RRF IS CALCULATED IN HPLC
what is the limit for KF Factor ,we take factor using water we will found factor between 6 to 7 ,while on KF Reagent bottle mentioned 5 mg/ml water content.if we not use dried methanol it is effect on factor.
what is the need of calulation of RRF of impurity in HPLC analysis?
what r the parts calibrated in gc
Why sulfuric acid is used in sulphated ash / residue on ignition test.
9 Answers CS Pharmaceuticals, Dr Reddys, GVK, HPLC, Micro Labs, Samrudh, Watson Pharmaceuticals, Wings Customer Care,
who is the father of HPLC?
Why we are using only KBr in IR spectrometer why not KCl
What is difference between known and unknown impurities
how you start the solubility study?
Organic Chemistry 
