Did HIV 1 & 2 speard through meanstural cycle?
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Answer / nithya.ng
The human immunodeficiency virus type 1 (HIV-1) infects
cells within mucosal tissues, including those of the female
reproductive tract (FRT). The mechanism of viral
transmission within the FRT and the mode of viral spread to
the periphery are not completely understood. We performed
phenotypical analyses and infectivity studies of primary
FRT cells to identify potential targets of infection within
the FRT. Our findings indicate that expression of HIV-1
receptors and coreceptors in the FRT varies as a function
of menstrual-cycle stage, suggesting that sex hormone
levels may influence a woman’s susceptibility to infection
by HIV-1. Moreover, HIV-1 strains that utilize the CXCR4
chemokine receptor for infectivity are able to undergo
reverse transcription, integration, viral DNA
transcription, and viral release, whereas viral strains
that utilize CCR5 do not undergo these early replicative
events, and are only released unmodified from these cells.
This indicates that several mechanisms for viral infection
and transmission are present throughout the FRT.
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