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what are DNA vaccines?
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Answer / swapna
Intramuscular injections of naked DNA expression plasmids
have been shown to generate immune responses. Such DNA
vaccines introduce tumor antigen genes into DCs for
endogenous processing and presentation to CTLs in draining
lymph nodes or into other cells for cross-presentation by
DCs, without the need for a viral vector. Thus, problems of
competition from viral vector epitopes, reduced efficacy
due to prior immunity to the viral vector, and potential
dangers associated with a live virus are avoided.
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Answer / bharath
Here the bacterial plasmid DNA bearing the gene sequence of
the antigen is injected directly onto the muscle of the
host. DNA is taken up by the muscle cells and are expressed
by them. These expressed proteins acts as antigens and
provides immunity.
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