why we are analyzing purity on HPLC why not in gc

Answers were Sorted based on User's Feedback



why we are analyzing purity on HPLC why not in gc..

Answer / sunil tiwari

Purity can be perform on the both the instrument HPLC as well as on GC, difference is that the:
1) If material is volatile in nature or can be converted easily in to the gaseous form, purity can be perform on GC, also material should be free from other substantial matters
2)If material is non-volatile, less volatile in nature or in liquid form, purity can be perform on HPLC,

Is This Answer Correct ?    34 Yes 1 No

why we are analyzing purity on HPLC why not in gc..

Answer / sandip bhasme

GC has it's own limitations. You cannot analyse non volatile
/ very high boiling point materials on GC. Commonly, If you
are using FID GC, You won't get polymer / inorganic
impurities on your chromatogram.

Is This Answer Correct ?    32 Yes 1 No

why we are analyzing purity on HPLC why not in gc..

Answer / kala

HPLC is a nondestructive method,gc is destructive

Is This Answer Correct ?    4 Yes 18 No

Post New Answer

More Analytical Chemistry Interview Questions

which procedure we follow if 6th month of accelerated sample fail?

1 Answers   Dr Reddys,


Who discovered X-ray

2 Answers   Huntsman Corporation,


pharma industries oriented

0 Answers   Apex, Micro Labs, Zydus Cadila,


importance of internal standard and in what conditions it is used?

1 Answers  


difference between HPLC & LC-MS

9 Answers   Lambda,






which are the guidelines for force degradation studies?

1 Answers  


what is the principle of UV Vis spectroscopy, AAS, ICP OES,ICPAES, ICP-MS and FTIR

0 Answers   Perkin Elmer,


what are the sources in ELSD,PDA, RI and UV Detectors?

1 Answers  


when we use pda detector in hplc instead of uv detector

6 Answers   Hetero,


how decide the clining method and cleaning method validation require for this perticular products?

0 Answers  


Why 1800 ml of dissolution media used In Carbamazepine ER USP Tablets But other drug only 900 ml Media Used ?

1 Answers   Torrent Pharma,


Which Pharmacopiea follow calibration of HPLC,GC

3 Answers   Bayer, Reddy Labs,


Categories
  • Organic Chemistry Interview Questions Organic Chemistry (342)
  • Inorganic Chemistry Interview Questions Inorganic Chemistry (123)
  • Analytical Chemistry Interview Questions Analytical Chemistry (1387)
  • Physical Chemistry Interview Questions Physical Chemistry (62)
  • General Chemistry Interview Questions General Chemistry (478)
  • Chemistry AllOther Interview Questions Chemistry AllOther (190)