what are the two types of methylmalonic acidemia(aciduria)?

Answers were Sorted based on User's Feedback



what are the two types of methylmalonic acidemia(aciduria)?..

Answer / shivani

MMA is caused by 3 main reasons -
1. functional impairment of enzyme methylmalonyl CoA mutase
[MCM] requiring Vitamin B12 as cofactor; which may be due
to mutations in MUT gene which codes the enzyme
2. mutations in genes reqiured for VitB12 processing &
transport
3. dietary deficiency of VitB12.

So depending on the cause there two major types of
methylmalonic aciduria [MMA]
1. Vitamin B12 responsive - the early [neonatal] onset &
severe type
2. Vitamin B12 - non responsive - the late onset & mild type

depending on the patient's response to VitB12 therapy.

Is This Answer Correct ?    2 Yes 0 No

what are the two types of methylmalonic acidemia(aciduria)?..

Answer / swapna

Methylmalonic acidemia (MMA, also known as "methylmalonic
aciduria") is an inborn error of intermediary metabolism
that may present in the early neonatal period with
progressive encephalopathy and death due to a secondary
hyperammonemia.


Methylmalonic acidemia is an inherited disorder in which
the body is unable to process certain proteins and fats
(lipids) properly. Methylmalonic acidemia is a disorder of
amino acid metabolism, involving a defect in the conversion
of methylmalonyl-coenzyme A (CoA) to succinyl-CoA.


Is This Answer Correct ?    0 Yes 1 No

Post New Answer

More Bio Chemistry Interview Questions

what is the important source for drug diosgenin?

1 Answers   Aurobindo,


What are the characteristics of an enzyme?

1 Answers   Wipro,


How to measure average peptide chain length

2 Answers  


is there a hormone in our body which when released induces sleep in us?is there a spurt in the secretion of that hormone in adolescence?why?

1 Answers  


DO POLYSACCHARIDES(STARCH)ANSWER BARFOED'S TEST?IF THEY DO,WHAT IS THE REASON?IF THEY DO NOT,WHAT IS THE REASON?

5 Answers  






Aromatic compounds generally undergo which type of reactions?

0 Answers  


What is the importance of enzymes for the living beings?

0 Answers  


What factors can change the pKa value of an amino acid residue, and in which direction?

0 Answers  


HOW HISTIDINE IS SYNTHESISED?

1 Answers  


What features do the helix and the sheet have in common?

4 Answers  


what is INFORMOSOME?

3 Answers   Ranbaxy,


WHAT IS MSG?

3 Answers   Biological.e.limited,


Categories