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WHAT IS THE IMPORTANCE OF NIGERICIN?
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Answer / moumita
Nigericin is an antibiotic derived from Streptomyces
hygroscopicus.Nigericin acts as an H+, K+, Pb2+ ionophore.
Most commonly it is an antiporter of H+ and K+.
In the past nigericin was used as an antibiotic active
against gram positive bacteria. It inhibits the Golgi
functions. Nigericin exhibits anti-HIV activity.
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It acts as an ionophore for k+ but in exchange for h+
abolishes the ph gradient across the membrane.in the
presence of both valinomycin and nigericin both the membrane
potential and ph gradient are eliminated and phosphorylation
is completly inhibited.
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