If we have 5 strength which is not dose proportinate and excipients also diffrent in each strength then how we can proceed for Force degradation? and excipient are same but not dose propotinate the how FD?
325If suppose 10 methods of dissolution given in pharmacopoeial for single content product then which method out of 10? or all 10 require to follow?
528how decide the clining method and cleaning method validation require for this perticular products?
297Post New Analytical Chemistry Questions
if content uniformity passing but dissolution varrying then what is next step?
How do we fix the sample concentaryion in hplc method development?
How to calibration of the uv spectroscopy and its test?
Why only hydroxy naphthol blue indicator is used for standardisation of 0.05M EDTA solution instead of solochrome Black T or Euriochrome Black T indicator which is used for all sample analysis with 0.05M EDTA solution?
What is the accrptance criteria in RSD for RS method precision on basis of impurity percentages?
What is the difference between chromatographic purity and related substances?
what is turbidimetric titration?Give 2 examples.
How we performed the force degradation for drug substance, is any specific guideline is available for each parameter(Acidic, basic, oxidation,heat)? what conditions you mentained for above parameters.
how to selecet an exact coloumn for an new molecule development by hplc how to select exact salt as buffer for new molecule development by hplc what is the the process to select the mode of saparation of compoundes by hplc what is the use of ph of buffer what is use of buffer,ph,organic phase,ans methods how the molecules get saparated in coloumn,
what is impurity profile. how to interpret this impurity profile to a drug product or drug substance.
why should we perform dissolution PVT calibration only by UV spectrometer, not by HPLC ?
sop of a uv visible spectrophotometer double beam elico model
In BP2013, Loperamid HCl monograph. Assay by titration with 0.1N sodium hydroxide using hydrocloric acid 0.01N and reading the volume added between the 2 points of inflexion. I have a question that if the diluent solvent is ethanol is certainly consumed a amount of volume of titrant, so this volume must be eliminated on the result calculation or not apart from first point which is subtracted above.
how require to select dissolution media? what is discrimination?
what is definition of validation? which components are followed give detail?
