Why we more noise in PDA detector compared to UV detector?



Why we more noise in PDA detector compared to UV detector?..

Answer / anil

There is no Integration function in the conventional UV-Vis spectrophotometer which
accumulates the signal. For example, the total required time will be 1000 sec. for 1000 data
points and it takes 1 sec. to measure one datum. In this case, all 1000 data have the same signal
to noise ratio (S/N).
But in a PDA instrument which has a 1000 photodiode array, 1000 data points can be
measured in 1 sec. and it would take 1/1000 sec. to achieve the same result obtainable in 1 sec.
in a conventional instrument. Therefore, when the same sample is measured for 1000 sec in a
PDA instrument, the signal is accumulated and is 1000 times greater than when measuring for 1
sec. The noise will be 10001/2
. This means that the S/N ratio is improved by 10001/2
.
This resulting benefit of fast data acquisition is termed Felgett’s S/N Advantage or
Multichannel Advantage

Is This Answer Correct ?    10 Yes 1 No

Post New Answer

More Analytical Chemistry Interview Questions

Basic principle of ESI?

0 Answers   Cipla, GVK,


how you start the solubility study?

0 Answers  


What is Delay & Dead Volume

2 Answers  


For standardization of volumetric solutions, acceptance limit for concentration is considered as 10% of nominal concentration and %RSD as NMT 0.2% (for appropriate no. of replicates). But , if %RSD has not met, what should be further action?

0 Answers  


what is the defferance between the potency and working standard

1 Answers   Arbro Pharmaceuticals, Caplin Point, ECOlogics, Matrix, Orchid, Venus Remedies,






what is different between volumetric solution and general solution

1 Answers  


what is the meaning of linearity,principle of co-relation coefficient?

3 Answers  


what is difference between IR & FTIR ? how we calibarte both ? I want to know the procedure.

7 Answers   Cadila,


If inhouse hplc related substance method is completly diffrent from Usp for finished proďuct with diffrent impurities then how require to prove method equivalecy?

0 Answers  


what is mean by assay?

6 Answers  


How are PDA Detector work in HPLC

7 Answers   Agilent,


why we are using benzene, anyline in acetic anhdride assay titration method?

0 Answers  


Categories
  • Organic Chemistry Interview Questions Organic Chemistry (342)
  • Inorganic Chemistry Interview Questions Inorganic Chemistry (123)
  • Analytical Chemistry Interview Questions Analytical Chemistry (1387)
  • Physical Chemistry Interview Questions Physical Chemistry (62)
  • General Chemistry Interview Questions General Chemistry (478)
  • Chemistry AllOther Interview Questions Chemistry AllOther (190)