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what is a difference between drug purity and drug potency?
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Answer / pooja
Potency is a measure of drug activity expressed in terms of
the amount required to produce an effect of given intensity.
Purity is a measure of the amount of API present in a sample
compared to those of related substances, impurities,
residual solvents, etc.
| Is This Answer Correct ? | 28 Yes | 0 No |
Answer / ravindra
Purity means other than impurity or absence of impurity &
we are calculating by area normalisation.
while Potency is content of that substances in the sample
and calculating it on dried basis ie. LOD, water content ,
residual solvent.
| Is This Answer Correct ? | 9 Yes | 4 No |
Hai
my humble request to all my dear friends please try to avoid false information and don't make confusion to learners try to provide good answers as per current requirements.so people may have good knowledge please i hope everyone has got my point,.
thanks
| Is This Answer Correct ? | 3 Yes | 2 No |
Answer / amit tiwari
Potency = purity-(LOD/Water content+residual solvents+total
impurities+ ROI)
Purity is a measure of the amount of API present in a sample
compared to those of related substances, impurities,
residual solvents, etc. now another term is purity is carried out by HPLC chromatographic purity and is % area of Main Peak where all peak integrated including all
known peaks due to product
| Is This Answer Correct ? | 1 Yes | 1 No |
Answer / santosh kumar
Purity is nothigbut assay value (i.e dried/as is basis).
Potency = assay-(LOD/Water content+residual solvents+total impurities)
| Is This Answer Correct ? | 16 Yes | 17 No |
Answer / monappa sutar
Drug purity means drug substance without any contaminant
(physical/chemical/biological) as it is indicated by
percent of assay.
Drug potency means efficasy of the drug substance that mens
the percent of specified biological/pharmacological effect
after administration.
| Is This Answer Correct ? | 4 Yes | 5 No |
Answer / dixit kachhia
Potency = purity-(LOD/Water content+residual solvents+total
impurities+ ROI)
PURITY IS CARRIED OUT BY HPLC CHROMATOGRAAPHIC PURITY AND IS
%AREA OF MAIN PEAK where all peak integrated including all
known and unknown peaks due to product
i am not in favored of potency calculated on basis of assay
rather than purity because assay calculated against another
std and there will be a possibility of no. of errors in
define correct assay.
| Is This Answer Correct ? | 0 Yes | 2 No |
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