what is sink condition in Dissolution?
Answers were Sorted based on User's Feedback
Answer / ram
In general the dissolution medium volume should be 3-10
times the saturation solubulity of the drug. Sink
conditions means thd drug which goes in to the solution is
not effected by the drug which not dissolved.
Is This Answer Correct ? | 192 Yes | 43 No |
Answer / indra kumar gupta
In sink condition, the volume of Medium is more than 5-10 folds of its saturation point & in anyway it Drug will not reach to its saturation point.
Is This Answer Correct ? | 57 Yes | 18 No |
Answer / k.gopal rao
which should be able to dissolve the expected amount of drug released from a product. This ability of the medium to dissolve the expected amount of drug is known as a “sink condition"
Is This Answer Correct ? | 23 Yes | 6 No |
the volume of the medium is at least 3 times garter than the volume of the medium in which the drug gets saturated
Is This Answer Correct ? | 16 Yes | 2 No |
Answer / ganesh parsewar
One of the requirements to conduct an appropriate drug
dissolution test is to use a sufficient volume of
dissolution medium, which should be able to dissolve the
expected amount of drug released from a product. This
ability of the medium to dissolve the expected amount of
drug is known as a “sink condition”.It is important to note
that a dissolution test should not be conducted in a volume
of the medium which would not dissolve the expected amount
of the drug completely and freely.
Is This Answer Correct ? | 22 Yes | 11 No |
Answer / apurva
sink condition is volume of medium greator than at least three times to form a saturated solution.with the help of sink condition we can fix vol of dissolution medium.as well as we can select dissolution medium for new drug substance.
Is This Answer Correct ? | 5 Yes | 1 No |
Answer / n bharth kumar
The concentration of drug at absorption site i.e.,GIT is more than in plasma level.....
It follows first order reaction(non linear graph)
Is This Answer Correct ? | 11 Yes | 16 No |
it is the condition at which the concentration of drug in
git is maintain greater then that of in plasma.
Is This Answer Correct ? | 4 Yes | 16 No |
Answer / ranjith
accordng to ficks first low c git is zero compare to c plasma .if have zero condition disslution is high
Is This Answer Correct ? | 5 Yes | 20 No |
Answer / honey
how much drug absorb its eliminated in same amount
Is This Answer Correct ? | 5 Yes | 37 No |
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