Bio Informatics Interview Questions

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What is the difference in terms of connectivity between a scale free network and random network?

652Suppose you used the NCBI Blast server to look for a match to a fruit-fly gene. Suppose further that the best alignment contained this section of an alignment: Hit from database: XXXXXXXXXXXXXXNFSTSQ User sequence: SLEAEAAPASISPSNFSSSQ What do the Xs signify?

736Suppose the Blast search returned 100 hits. Of these, 17 were false positives and we knew that there were 165 sequences in the database which should have returned a hit with our sequence. How many false negatives were there, and what is the sensitivity and selectivity of Blast in this instance?

877If a match from a sequence database search is reported to have an E-value of 0.0, should it be considered highly insignificant or highly significant?

What is the idea behind ?weighting? sequences in the package CLUSTAL W for multiple alignment? How are these weights calculated?

759When a bicycle is in motion, the force of friction exerted by the ground on the two wheels is such that it acts a) In the backward direction on the front wheel and in the forward direction on the rear wheel. (b) In the forward direction on the front wheel and in the backward direction on the rear wheel. (c) In the backward direction on both the front and rear wheels. (d) In the backward direction on both the front and rear wheels.

A certain radioactive element A, has a half life = t seconds. In (t/2) seconds the fraction of the initial quantity of the element so far decayed is nearly (a) 29% (b) 15% (c) 10% (d) 45%

Which of the following plots would be a straight line ? (a) Logarithm of decay rate against logarithm of time (b) Logarithm of decay rate against logarithm of number of decaying nuclei (c) Decay rate against time (d) Number of decaying nuclei against time

A radioactive element x has an atomic number of 100. It decays directly into an element y which decays directly into element z. In both processes a charged particle is emitted. Which of the following statements would be true? (a) y has an atomic number of 102 (b) y has an atomic number of 101 (c) z has an atomic number of 100 (d) z has an atomic number of 101

If the sum of the roots of the equation ax2 + bx + c=0 is equal to the sum of the squares of their reciprocals then a/c, b/a, c/b are in (a) AP (b) GP (c) HP (d) None of these

A man speaks the truth 3 out of 4 times. He throws a die and reports it to be a 6. What is the probability of it being a 6? (a) 3/8 (b) 5/8 (c) 3/4 (d) None of the above

If cos2A + cos2B + cos2C = 1 then ABC is a (a) Right angle triangle (b) Equilateral triangle (c) All the angles are acute (d) None of these

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Un-Answered Questions { Bio Informatics }

How to Insert Genomic DNA into yeast ?

How to find flanking region ?

What are the main differences between parsimony,distance and likelihood-based algorithms?

How to Count number of nucleotide substitutions ?

what is an active ? (UML)

An electron is injected into a region of uniform magnetic flux density with the components of velocity parallel to and normal to the flux. What is the path of the electron?

How to find a sequence of dna molecule?

How to find coexpressed genes on NCBI GEO?

How to caculate coordinates of each atoms on 3 D HP model?

A certain radioactive element A, has a half life = t seconds. In (t/2) seconds the fraction of the initial quantity of the element so far decayed is nearly how much?

Can DeCypher be used for protein struc-ture modeling?

Bootstrap analysis evaluates evolutionary trees by sampling columns from the original alignment with replacement (multiplying or removing some of them) and computing a proportion of times that a particular branch appears in the resulting trees. What is the main idea behind this approach?

what is the principle involved in Biometry?

What are the current challenges in the Pharmaceutical and biotechnology sectors?

what is the image of point (3,8) in the line x + 3y = 7 ?