Bio Informatics Interview Questions

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What is the difference in terms of connectivity between a scale free network and random network?

675Suppose you used the NCBI Blast server to look for a match to a fruit-fly gene. Suppose further that the best alignment contained this section of an alignment: Hit from database: XXXXXXXXXXXXXXNFSTSQ User sequence: SLEAEAAPASISPSNFSSSQ What do the Xs signify?

758Suppose the Blast search returned 100 hits. Of these, 17 were false positives and we knew that there were 165 sequences in the database which should have returned a hit with our sequence. How many false negatives were there, and what is the sensitivity and selectivity of Blast in this instance?

903If a match from a sequence database search is reported to have an E-value of 0.0, should it be considered highly insignificant or highly significant?

What is the idea behind ?weighting? sequences in the package CLUSTAL W for multiple alignment? How are these weights calculated?

778When a bicycle is in motion, the force of friction exerted by the ground on the two wheels is such that it acts a) In the backward direction on the front wheel and in the forward direction on the rear wheel. (b) In the forward direction on the front wheel and in the backward direction on the rear wheel. (c) In the backward direction on both the front and rear wheels. (d) In the backward direction on both the front and rear wheels.

A certain radioactive element A, has a half life = t seconds. In (t/2) seconds the fraction of the initial quantity of the element so far decayed is nearly (a) 29% (b) 15% (c) 10% (d) 45%

Which of the following plots would be a straight line ? (a) Logarithm of decay rate against logarithm of time (b) Logarithm of decay rate against logarithm of number of decaying nuclei (c) Decay rate against time (d) Number of decaying nuclei against time

A radioactive element x has an atomic number of 100. It decays directly into an element y which decays directly into element z. In both processes a charged particle is emitted. Which of the following statements would be true? (a) y has an atomic number of 102 (b) y has an atomic number of 101 (c) z has an atomic number of 100 (d) z has an atomic number of 101

If the sum of the roots of the equation ax2 + bx + c=0 is equal to the sum of the squares of their reciprocals then a/c, b/a, c/b are in (a) AP (b) GP (c) HP (d) None of these

A man speaks the truth 3 out of 4 times. He throws a die and reports it to be a 6. What is the probability of it being a 6? (a) 3/8 (b) 5/8 (c) 3/4 (d) None of the above

If cos2A + cos2B + cos2C = 1 then ABC is a (a) Right angle triangle (b) Equilateral triangle (c) All the angles are acute (d) None of these

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Un-Answered Questions { Bio Informatics }

Define perl and clustalW problem?

Explain about needleman-wunsch algorithm?

what is a qi number?

What is a DNA array?

What is the criteria for LTQ (LC-MS/MS) SEQUEST search?

A certain radioactive element A, has a half life = t seconds. In (t/2) seconds the fraction of the initial quantity of the element so far decayed is nearly how much?

NLO : RPS : : ? : ZXA

How can we find the direction of an nucleotide substitution, for example; C to T or T to C?

what is the principle involved in Biometry?

How to find a sequence of dna molecule?

How to Insert Genomic DNA into yeast ?

How the Algorithm works?

What two possibilities are there to describe how gene fragments may have evolved?

How long will a train 100m long traveling at 72kmph take to overtake another train 200m long traveling at 54kmph?

What is Phantom Gene Sequence?