Bio Informatics Interview Questions

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What is the difference in terms of connectivity between a scale free network and random network?

763Suppose you used the NCBI Blast server to look for a match to a fruit-fly gene. Suppose further that the best alignment contained this section of an alignment: Hit from database: XXXXXXXXXXXXXXNFSTSQ User sequence: SLEAEAAPASISPSNFSSSQ What do the Xs signify?

851Suppose the Blast search returned 100 hits. Of these, 17 were false positives and we knew that there were 165 sequences in the database which should have returned a hit with our sequence. How many false negatives were there, and what is the sensitivity and selectivity of Blast in this instance?

1025If a match from a sequence database search is reported to have an E-value of 0.0, should it be considered highly insignificant or highly significant?

What is the idea behind ?weighting? sequences in the package CLUSTAL W for multiple alignment? How are these weights calculated?

856When a bicycle is in motion, the force of friction exerted by the ground on the two wheels is such that it acts a) In the backward direction on the front wheel and in the forward direction on the rear wheel. (b) In the forward direction on the front wheel and in the backward direction on the rear wheel. (c) In the backward direction on both the front and rear wheels. (d) In the backward direction on both the front and rear wheels.

A certain radioactive element A, has a half life = t seconds. In (t/2) seconds the fraction of the initial quantity of the element so far decayed is nearly (a) 29% (b) 15% (c) 10% (d) 45%

Which of the following plots would be a straight line ? (a) Logarithm of decay rate against logarithm of time (b) Logarithm of decay rate against logarithm of number of decaying nuclei (c) Decay rate against time (d) Number of decaying nuclei against time

A radioactive element x has an atomic number of 100. It decays directly into an element y which decays directly into element z. In both processes a charged particle is emitted. Which of the following statements would be true? (a) y has an atomic number of 102 (b) y has an atomic number of 101 (c) z has an atomic number of 100 (d) z has an atomic number of 101

If the sum of the roots of the equation ax2 + bx + c=0 is equal to the sum of the squares of their reciprocals then a/c, b/a, c/b are in (a) AP (b) GP (c) HP (d) None of these

A man speaks the truth 3 out of 4 times. He throws a die and reports it to be a 6. What is the probability of it being a 6? (a) 3/8 (b) 5/8 (c) 3/4 (d) None of the above

If cos2A + cos2B + cos2C = 1 then ABC is a (a) Right angle triangle (b) Equilateral triangle (c) All the angles are acute (d) None of these

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Un-Answered Questions { Bio Informatics }

What does the ultrametric property of a tree tell us about the evolutionary process?

How the Algorithm works?

How to find flanking region ?

What is Phantom Gene Sequence?

What is C-compliator?

How can we find the direction of an nucleotide substitution, for example; C to T or T to C?

What is a DNA array?

A certain radioactive element A, has a half life = t seconds. In (t/2) seconds the fraction of the initial quantity of the element so far decayed is nearly how much?

Bootstrap analysis evaluates evolutionary trees by sampling columns from the original alignment with replacement (multiplying or removing some of them) and computing a proportion of times that a particular branch appears in the resulting trees. What is the main idea behind this approach?

what is a qi number?

Suppose the Blast search returned 100 hits. Of these, 17 were false positives and we knew that there were 165 sequences in the database which should have returned a hit with our sequence. How many false negatives were there, and what is the sensitivity and selectivity of Blast in this instance?

can u give me an example of a project you were involved with that illustrates your interest and skills in bringing people together?

What are the main differences between parsimony,distance and likelihood-based algorithms?

What two possibilities are there to describe how gene fragments may have evolved?

How to find coexpressed genes on NCBI GEO?