Is sonication essential in solubility testing of a drug
substance?
- 6 Answers
- 14438 Views
- Aurobindo, I also Faced
- E-Mail Answers
Answers were Sorted based on User's Feedback
Answer / hemant mhaske
FOR THE SOLUBILITY TESTING SONICATION IS NOT REQUIRRED B,COZ WE ARE DETERMINING SOLUBILITY OF COMPOUND IN SUITABLE SOLVENT. MEANS IN WHICH SOLVENT IT IS FREELY SOLUBLE AND IN WHICH SOLVENT LESS SOLUBLE..
| Is This Answer Correct ? | 11 Yes | 0 No |
Answer / pharmainterview
There is no guideline which specifies the sonication
required or not for solubility. So some people prefer to
sonicate and other not. You can't say which one is wright
because you have no evidenced guideline.
Regards
pharmainterviewquestions.blogspot.in
| Is This Answer Correct ? | 8 Yes | 2 No |
Answer / manjeera
sonication is not exactly required for a solubility test of drug substance it is preferable sometimes to check whether it is soluble when it is sonicated.
| Is This Answer Correct ? | 5 Yes | 1 No |
Answer / pradeep reddy
no need to use of sonicate.because substances will freely
soluble in diluent.by hand shake or spinic we can do that
test.
| Is This Answer Correct ? | 2 Yes | 1 No |
Answer / msreddyvelagala
sonication is not mentioned in usp&EP.solubility is checked by handshaking for 1 minute &put it at temperature 20 or 25c for some time.
| Is This Answer Correct ? | 1 Yes | 0 No |
Answer / devendra
There is no need to sonication if it say very soluble, freely soluble, soluble...
In case of practically soluble we can use sonication.
| Is This Answer Correct ? | 2 Yes | 1 No |
why we are performing residue on ignition?
which functional group we can detect in IR?
Why 1800 ml of dissolution media used In Carbamazepine ER USP Tablets But other drug only 900 ml Media Used ?
How we can determine OOT limit in Stability
How you will select the runtime in HPLC for a drug in method development.
6 Answers Aurobindo, GVK, Lesanto Laboratories,
In standard weight box used for calibration of analytical balance there are two numbers (Qty) of 20mg, 200mg,2.oGM weights. Why?
are there in uv lamb that is chractrestic for wavelenghth 205 nm ?????
1 Answers Beni Suef University, Graviti Pharmaceuticals, Sri Krishna Pharmaceuticals,
why we use glass fiber filters use in some situation?
why 0.005 M sulphuric acid is used to calbrate spectrophotometer and why caffiene is used for calibrating hplc
2 Answers GVK, Torrent Pharma,
what type of compounds do we see lod @ wat type compounds do we see m.c
Why red HgI2 added during starch preparation?
what is mean by assay?
Organic Chemistry 
