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what is sink condition in Dissolution?
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Answer / ram
In general the dissolution medium volume should be 3-10
times the saturation solubulity of the drug. Sink
conditions means thd drug which goes in to the solution is
not effected by the drug which not dissolved.
| Is This Answer Correct ? | 192 Yes | 43 No |
Answer / indra kumar gupta
In sink condition, the volume of Medium is more than 5-10 folds of its saturation point & in anyway it Drug will not reach to its saturation point.
| Is This Answer Correct ? | 57 Yes | 18 No |
Answer / k.gopal rao
which should be able to dissolve the expected amount of drug released from a product. This ability of the medium to dissolve the expected amount of drug is known as a “sink condition"
| Is This Answer Correct ? | 23 Yes | 6 No |
the volume of the medium is at least 3 times garter than the volume of the medium in which the drug gets saturated
| Is This Answer Correct ? | 16 Yes | 2 No |
Answer / ganesh parsewar
One of the requirements to conduct an appropriate drug
dissolution test is to use a sufficient volume of
dissolution medium, which should be able to dissolve the
expected amount of drug released from a product. This
ability of the medium to dissolve the expected amount of
drug is known as a “sink condition”.It is important to note
that a dissolution test should not be conducted in a volume
of the medium which would not dissolve the expected amount
of the drug completely and freely.
| Is This Answer Correct ? | 22 Yes | 11 No |
Answer / apurva
sink condition is volume of medium greator than at least three times to form a saturated solution.with the help of sink condition we can fix vol of dissolution medium.as well as we can select dissolution medium for new drug substance.
| Is This Answer Correct ? | 5 Yes | 1 No |
Answer / n bharth kumar
The concentration of drug at absorption site i.e.,GIT is more than in plasma level.....
It follows first order reaction(non linear graph)
| Is This Answer Correct ? | 11 Yes | 16 No |
it is the condition at which the concentration of drug in
git is maintain greater then that of in plasma.
| Is This Answer Correct ? | 4 Yes | 16 No |
Answer / ranjith
accordng to ficks first low c git is zero compare to c plasma .if have zero condition disslution is high
| Is This Answer Correct ? | 5 Yes | 20 No |
Answer / honey
how much drug absorb its eliminated in same amount
| Is This Answer Correct ? | 5 Yes | 37 No |
what do you mean by mean kinetic temperature in stability
If we get 100% assay of an Initial sample ,and the stability studies of the same sample got 90% dissolution result, and when the same stability sample was analyzed for RS studies no impurities was found . Where the 10% Active substance were gone during dissolution analysis.Please help me in getting the conclusion.
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