Answer Posted / t.venkata reddy
below reasons causes peak tailing
1)Analytical column contaminated
2)Mobile phase contamination/deterioation
3)unswept dead volume
4)basic substance-silanol interation.
Is This Answer Correct ? | 2 Yes | 0 No |
Post New Answer View All Answers
What is third generation HPLC Columns?
why are measure gas flow " ml " in Gas chromatography
in which situation require to take incident in validation?
what is mean by nitrosamine impurities?
what is difference between UV - VISIBLE MODEL NO like 1600,1601,1700 etc ? plz explain me
My question about gas chromatography sulfur chemiluminsecence detector. I test unknown sample gas by GC-SCD (calibrated ) and the result of *H2S is 279 PPM , *but when I test the same sample with the GC-TCD (calibrated ) the value of *H2S is 2500 PPM . I'd like to inform you that both GCs are calibrated and have very good operation conditions with stable parameters . the question is if the sample gas with higher H2S over detection limits of SCD detector (1000 ppm). why the result it 279 ppm Best regards
how we can identify the impurity is coming below loq at transfering site?
How you develop a method in HPLC?
How will u perform degradation study in detectors other thann PDA in HPLC Methodology
if you get peak in blank then what require to do?
which batch require to use for analytical method validation?
If we have 5 strength which is not dose proportinate and excipients also diffrent in each strength then how we can proceed for Force degradation? and excipient are same but not dose propotinate the how FD?
what is difference in ods I ods II is this is realy from sorbent / packing characteristics or from other means
what is classification of elemental impurities? what is risk assement in elemental impurities?
How do we fix the sample concentaryion in hplc method development. What is the basis?